745048-17-3

Basic information

• Product Name: 1,1,1-triphenyl-2,5,8,11,14,17,20-heptaoxadocosan-22-ol
• Synonyms: 1,1,1-triphenyl-2,5,8,11,14,17,20-heptaoxadocosan-22-ol
• CAS NO: 745048-17-3
• Molecular Weight: 568.708
• Mol File: 745048-17-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,1,1-triphenyl-2,5,8,11,14,17,20-heptaoxadocosan-22-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1,1-triphenyl-2,5,8,11,14,17,20-heptaoxadocosan-22-ol(745048-17-3)
• EPA Substance Registry System: 1,1,1-triphenyl-2,5,8,11,14,17,20-heptaoxadocosan-22-ol(745048-17-3)

Safety Data

• Hazardous Substances Data: 745048-17-3(Hazardous Substances Data)

Usage

Structure

A long chain of oxygen atoms (22 in total) with three phenyl groups attached to the first carbon atom.

Type of Compound

Polyethylene glycol derivative

Repeating Units

Ethylene glycol (-CH2-CH2-O-)

Industrial Applications

Commonly used as a surfactant in industrial and cosmetic products.

Properties

a. Reduces surface tension
b. Improves wetting and spreading properties

Additional Applications

a. Pharmaceuticals
b. Component in polymers and elastomers

Unique Structure

Valuable additive in various fields of chemistry and industry.

Upstream product

• 76-84-6 triphenylmethyl alcohol 
• 133699-09-9 10,10,10-triphenyl-3,6,9-trioxadecan-1-ol 
• 146462-59-1 1-(methylsulfonyl)-10-(triphenylcarbinyl)-1,4,7,10-tetraoxadecane 
• 76-83-5 trityl chloride 
• 112-60-7 Tetraethylene glycol 
• 127999-16-0 19-(triphenylmethyl)-1,4,7,10,13,16,19-heptaoxanonadecanol 
• 107-21-1 ethylene glycol 
• 745048-16-2 19,19,19-triphenyl-3,6,9,12,15,18-hexaoxanonadec-1-ylmethanesulfonate 
• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 

Downstream Products

• 850723-16-9 methanesulfonic acid 2-{2-[2-(2-{2-[2-(2-trityloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethyl ester 
• 5617-32-3 heptaethylene glycol 
• 745048-18-4 22-azido-1,1,1-triphenyl-2,5,8,11,14,17,20-heptaoxadocosane 
• 1274892-60-2 2-{2-[2-(2-{2-[2-(2-azido-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethanol 

Relevant articles and documents

Highly efficient synthesis of monodisperse poly(ethylene glycols) and derivatives through macrocyclization of oligo(ethylene glycols)

A macrocyclic sulfate (MCS)-based approach to monodisperse poly(ethylene glycols) (M-PEGs) and their monofunctionalized derivatives has been developed. Macrocyclization of oligo(ethylene glycols) (OEGs) provides MCS (up to a 62-membered macrocycle) as versatile precursors for a range of monofunctionalized M-PEGs. Through iterative nucleophilic ring-opening reactions of MCS without performing group protection and activation, a series of M-PEGs, including the unprecedented 64-mer (2850Da), can be readily prepared. Synthetic simplicity coupled with versatility of this new strategy may pave the way for broader applications of M-PEGs. Macrocycles make synthesis easier: Convenient macrocyclization of the OEGs provides versatile macrocyclic sulfates. These compounds are cornerstones for both monofunctionalization of OEGs and highly efficient synthesis of monodisperse PEGs and derivatives, including an unprecedented 64-mer.

Fluorescent pirenzepine derivatives as potential bitopic ligands of the human M1 muscarinic receptor

Following a recent description of fluorescence resonance energy transfer between enhanced green fluorescent protein (EGFP)-fused human muscarinic M1 receptors and Bodipy-labeled pirenzepine, we synthesized seven fluorescent derivatives of this antagonist in order to further characterize ligand-receptor interactions. These compounds carry Bodipy [558/568], Rhodamine Red-X [560/580], or Fluorolink Cy3 [550/570] fluorophores connected to pirenzepine through various linkers. All molecules reversibly bind with high affinity to M1 receptors (radioligand and energy transfer binding experiments) provided that the linker contains more than six atoms. The energy transfer efficiency exhibits modest variations among ligands, indicating that the distance separating EGFP from the fluorophores remains almost constant. This also supports the notion that the fluorophores may bind to the receptor protein. Kinetic analyses reveal that the dissociation of two Bodipy derivatives (10 or 12 atom long linkers) is sensitive to the presence of the allosteric modulator brucine, while that of all other molecules (15-24 atom long linkers) is not. The data favor the idea that these analogues might interact with both the acetylcholine and the brucine binding domains.