7454-68-4

Upstream product

• 95-78-3 2,5-Dimethylaniline 
• 98-60-2 4-chlorobenzenesulfonyl chloride 
• 2751-25-9 p-chlorophenylsulfonyl hydrazide 
• 4547-68-6 p-chlorobenzenesulfonyl azide 
• 106-42-3 para-xylene 

Relevant academic research and scientific papers

Synthesis, antibacterial and lipoxygenase activities of N-[(dimethyl substituted)phenyl]-N-(4-chlorophenyl)-4-chlorobenzenesulfonamides

In present research work, a new series of N-[(dimethyl substituted)phenyl]-N-(4-chlorophenyl)-4-chlorobenzenesulfonamides (5a-f) was synthesized and also evaluated for their biological activities. The reaction of 4-chlorobenzenesulfonyl chloride (1) with dimethyl substituted aniline (2a-f) in aqueous alkaline medium yielded N-[(dimethyl substituted)phenyl]-4-chlorobenzenesulfonamides (3a-f). The target compounds 5a-f were synthesized by reacting the compounds 3a-f with electrophile, 4-chlorobenzyl chloride (4) in aprotic solvent, DMF and NaH. All the synthesized compounds were characterized by IR, 1H NMR and EIMS. All the synthesized derivatives were screened for antibacterial potential and were also subjected for lipoxygenase enzyme inhibition activity.

Synthesis, structural analysis and pharmacological screening of chlorinated sulfonamides

In present work, a facile and environmentally benign series of chlorinated sulfonamides was synthesized and screened against different enzymes. These were geared up by the coupling of 4-chlorobenzenesulfonyl chloride (1) with different substituted aromatic amines (2a-l) under dynamic pH control in aqueous media to form various chlorinated sulfonamides (3a-l). The synthesized chlorinated sulfonamides were spectrally characterized like 1H NMR, IR and EI-MS. The bioactivity of all the synthesized compounds were evaluated against urease, butyrylcholinesterase (BChE) and lipoxygenase (LOX) enzymes and found to be having talented activity against butyrylcholinesterase enzyme.