74590-75-3

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 39695-64-2 2-(hydroxymethylene)cyclohexanone 
• 823-45-0 2-(hydroxymethylene)cyclohexanone 
• 108-94-1 cyclohexanone 

Downstream Products

• 102736-37-8 methyl 2-(phenylthio)-5,6,7,8-tetrahydronaphthalene-1-carboxylate 
• 107647-55-2 1-Benzyl-2-[1-trimethylsilanyloxy-meth-(E)-ylidene]-cyclohexanol 
• 107647-56-3 2-Benzyl-cyclohex-1-enecarbaldehyde 
• 59604-96-5 2-hydroxy-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Synthesis and Antitumor Activity of Simple Vinyl and α-Methylene-γ-butyrolactone Sulfonate Esters and Silyl Enol Ethers

A number of simple silyl enol ethers and vinyl trifluoromethanesulfonates, a relatively new class of organic compounds capable of undergoing alkylation by a nucleophilic addition-elimination process, were evaluated in the P388 lymphocytic leukemia system.

Synthesis of bicyclic salicylates by [3+3] cyclization of 1,3-bis(silyl enol ethers) with cyclic 3-(silyloxy)alk-2-en-1-ones

Bicyclic salicylates were prepared by [3+3] cyclization of 1,3-bis(silyl enol ethers) with cyclic 3-(silyloxy)alk-2-en-1-ones.

AROMATIC ANNELATION. SYNTHESIS OF NAPHTHALENES.

An efficient cationic cyclization reaction has been developed to prepare substituted naphthalenes.The method has been used to prepare a phenanthrene and will be useful for the synthesis of polynuclear aromatic hydrocarbons and C-glycosyl anthraquinones.

A Novel Cycloaromatization Reaction. Regiocontrolled Synthesis of Substituted Methyl Salicylates

A new method of constructing six-membered rings, involving the condensation of two three-carbon units, one with two nucleophilic sites and the other containing two electrophilic sites, is reported.The regiochemistry of the reaction is controlled by the differential reactivities of these sites. 1,3-Bis(trimethylsiloxy)-1-methoxybuta-1,3-diene (1) constitutes the three-carbon fragment with two nucleophilic sites.Condensation of 1 with various equivalents of β-dicarbonyl compounds and titanium tetrachloride gave substituted methyl salicylates.The regiochemistry is controlled by the order of reactivity of the electrophilic sites, which is conjugate position of enone > ketone > monothioacetal, acetal.