Synthesis and Antitumor Activity of Simple Vinyl and α-Methylene-γ-butyrolactone Sulfonate Esters and Silyl Enol Ethers

Article abstract of DOI:10.1021/jm00136a019

A number of simple silyl enol ethers and vinyl trifluoromethanesulfonates, a relatively new class of organic compounds capable of undergoing alkylation by a nucleophilic addition-elimination process, were evaluated in the P388 lymphocytic leukemia system.