7462-05-7

Basic information

• Product Name: Benzoic acid, 4-nitro-,2-(1-methylethylidene)hydrazide
• Synonyms: Benzoicacid, 4-nitro-, (1-methylethylidene)hydrazide (9CI); NSC 404142; p-Nitrobenzoicacid isopropylidene hydrazide
• CAS NO: 7462-05-7
• Molecular Formula: C10H11 N3 O3
• Molecular Weight: 221.216
• Mol File: 7462-05-7.mol

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-nitro-,2-(1-methylethylidene)hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-nitro-,2-(1-methylethylidene)hydrazide(7462-05-7)
• EPA Substance Registry System: Benzoic acid, 4-nitro-,2-(1-methylethylidene)hydrazide(7462-05-7)

Safety Data

• Hazardous Substances Data: 7462-05-7(Hazardous Substances Data)

Upstream product

• 636-97-5 N-amino-(4-nitrophenyl)carboxamide 
• 67-64-1 acetone 
• 99-77-4 ethyl 4-nitrobenzoate 
• 619-50-1 4-nitrobenzoic acid methyl ester 

Downstream Products

• 59811-91-5 4-nitro-benzoic acid N'-isopropyl-hydrazide 
• 1073675-79-2 3-[2-(4-chlorophenyl)-2-oxoethyl]-3-hydroxy-2-(4-nitrobenzoyl)-6-phenyl-2,3-dihydropyridazin-4(1H)-one 
• 63313-07-5 nickel(II) acetone 4-nitrobenzoylhydrazone 
• 58466-70-9 Co((CH₃)2CNNC(O)C₆H₄NO₂-p)2(C₅H₅N)2 
• 1260116-76-4 diethyl {1-methyl-1-[2-(4-nitrobenzoyl)hydrazino]ethyl}phosphonate 
• 58466-53-8 Co((CH₃)2CNNHC(O)C₆H₄NO₂-p)2Cl₂ 
• 92573-99-4 2-methoxy-5,5-dimethyl-2-(4-nitrophenyl)-Δ³-1,3,4-oxadiazoline 

Relevant articles and documents

Effect of ligand substituents on supramolecular self-assembly and electrochemical properties of copper(II) complexes with benzoylhydrazones: X-ray crystal structures and cyclic voltammetry

Complexation of copper(II) with a series of hetero-donor chelating Schiff bases (HLLR) of para-substituted benzhydrazides (with R = OH, NO 2, CH3O, Cl and tert-butyl substituents) and acetone affords mononuclear [Cu(LLR)2] molecules: 1 [Cu(anbhz)2] (R = NO2); 2 [Cu(ahbhz)2] (R = OH) 3 [Cu(ambhz)2] (R = CH3O); 4 [Cu(acbhz)2] (R = Cl); and 5 [Cu(atbhz)2] (R = tert-butyl). Single-crystal X-ray diffraction results for 2-5 reveal their various supramolecular architectures including 1D and 2D dimensionalities. A detailed analysis of crystal structures allows to gain insight into intermolecular interactions accountable for self-assembly into different networks as well as for various physicochemical properties of the compounds. The major interactions include O-H...N hydrogen bonds (2) as well as CH...N and axial Cu...O (3); π...π stacking (4) and van der Waals CH...C interactions (5). All compounds are characterized by elemental analyses; IR and UV-Vis spectroscopy as well as magnetic susceptibility and cyclic voltammetry measurements. Electrochemical studies reveal the dependence of [Cu(LL R)2]/[Cu(LLR)2]- reduction potentials on substituents of benzoylhydrazonoate ligands.

Benzoylhydrazones in catalytic hydrophosphorylation

Reactions of benzoylhydrazones derived from heterocyclic and aromatic aldehydes and aliphatic, heterocyclic, and aliphatic-aromatic ketones with diethyl phosphite in the presence of [tetra(tert-butyl)phthalocyanine]aluminum chloride afford α-benzoylhydraz

Diacylglycerol acyltransferase inhibitors

Provided herein are compounds of the formula (1): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.

An efficient synthesis of substituted hydrazides

Routes for the selective synthesis of 1-, or 2-substituted hydrazides, and 1,2-disubstituted hydrazides are reported. These routes proceed via cyanoborohydride reduction of stable acyl hydrazone intermediates. Georg Thieme Verlag Stuttgart.