7465-96-5

Usage

Uses

Used in Organic Synthesis:
N-(4-bromophenyl)-4-methoxybenzamide is used as a building block for the synthesis of various organic compounds. Its unique structure allows for the formation of new chemical bonds and the creation of diverse molecules with different properties.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, N-(4-bromophenyl)-4-methoxybenzamide is used as a precursor for the development of pharmaceuticals and biologically active molecules. Its structural features make it a valuable component in the design and synthesis of new drugs with potential therapeutic applications.
Used in Research and Development:
Due to its potential pharmacological properties and applications in chemical and pharmaceutical industries, N-(4-bromophenyl)-4-methoxybenzamide is used in research and development efforts to explore its full potential and discover new uses. This includes investigating its interactions with biological systems and evaluating its efficacy in various applications.

InChI:InChI=1/C14H12BrNO2/c1-18-13-8-2-10(3-9-13)14(17)16-12-6-4-11(15)5-7-12/h2-9H,1H3,(H,16,17)

Upstream product

• 100-07-2 4-methoxy-benzoyl chloride 
• 106-40-1 4-bromo-aniline 
• 3424-93-9 4-methoxyphenylacetamide 
• 589-87-7 1,4-bromoiodobenzene 
• 62-53-3 aniline 
• 7465-88-5 4-methoxy-N-phenylbenzamide 
• 58618-94-3 benzoic p-methoxybenzoic anhydride 

Downstream Products

• 127351-04-6 N-(4-Bromo-phenyl)-4-methoxy-thiobenzamide 
• 154558-92-6 6-bromo-2-(4-methoxyphenyl)-1,3-benzothiazole 

Relevant academic research and scientific papers

Activated charcoal supported copper nanoparticles: A readily available and inexpensive heterogeneous catalyst for the N-arylation of primary amides and lactams with aryl iodides

A novel heterogeneous copper catalyst has been developed by supporting copper nanoparticles on activated charcoal via in situ reducing copper(II) with aqueous hydrazine as reductant. The characterization of Cu/C catalyst showed that the Cu0 nano-particles were formed on the surface of charcoal. This catalyst displayed good catalytic activities toward the N-arylation of primary amides and lactams with aryl iodides.

RADIOLABELED COMPOUNDS

The present invention relates to radiolabeled compounds of formula (I) wherein either A, B, R1, R2, is labeled with a radionuclide selected from 3H, 11C and 18F and its use for imaging alpha synuclein and/or Abeta deposits in mammals.

Combining Eosin y with Selectfluor: A Regioselective Brominating System for Para-Bromination of Aniline Derivatives

A mild, metal-free, and absolutely para-selective bromination of aniline derivatives has been developed in excellent yields, wherein the organic dye Eosin Y is employed as the bromine source in company with Selectfluor. Neither air nor moisture sensitive, this facile reaction proceeds smoothly at room temperature and completes within a short time. Mechanistic studies indicate a radical pathway; therefore, the existence of an in situ generated brominating reagent, "Selectbrom", is postulated, which may reasonably account for the unique regioselectivity for the para-bromination of N-acyl- as well as N-sulfonylanilines.

Hypervalent Iodine-Mediated Oxidative Rearrangement of N-H Ketimines: An Umpolung Approach to Amides

An umpolung approach to amides via hypervalent iodine-mediated oxidative rearrangement of N-H ketimines under mild reaction conditions is described. This strategy provides target amides with excellent selectivity in good yields. In addition, preliminary m

Synthesis, anticancer activity and docking of some substituted benzothiazoles as tyrosine kinase inhibitors

Protein tyrosine kinases occupy a central position in the control of cellular proliferation and its inactivation might lead to the discovery of a new generation anticancer compounds. Substituted benzothiazoles have been found to mimic the ATP-competitive

Therapeutic compounds

Compounds of the formula (I) for use as an estrogen receptor-β-selective ligand are described wherein: X is O or S; and R1, R3 R6 are as described in the specification. The use of these compounds in treating Alzheimer's disease, anxiety disorders, depressive disorders, osteoporosis, cardiovascular disease, rheumatoid arthritis and prostate cancer is described; as are processes for making them.

Polyaromatic scavenger reagents (PAHSR): A new methodology for rapid purification in solution-phase combinatorial synthesis

(Formula presented) A new method of purification of solution-phase combinatorial libraries has been developed. Development of a chemically inert polyaromatic anchor with a reactive "scavenger reagent" (PAHSR) allows unreacted reagents and impurities to be removed from a reaction by absorption of the PAHSR to charcoal and simple filtration.

KINETICS AND MECHANISM OF THE AMINOLYSIS OF BENZOIC ANHYDRIDES

Nucleophilic substitution reactions of benzoic anhydrides, in which one of the rings is substituted, with anilines were investigated in methanol.The product-formation step coincides with the rate-limiting step so that the two rate constants, kXY and kXZ, for the competitive reaction pathways can be dissected.The two cross-interaction constants, ρXY and ρXZ, especially an unusually large magnitude of the latter, indicate that the reaction proceeds by a frontside SN2 attack on either one of the carbonyl carbon with a strong interaction between the nucleophile (X) and the leaving group (Z).The mechanism is also supposed by the trends in the activation parameters.