746667-09-4

Basic information

• Product Name: [1,2,4]Triazolo[1,5-a]pyridine, 6-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-
• Synonyms: [1,2,4]Triazolo[1,5-a]pyridine, 6-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-
• CAS NO: 746667-09-4
• Molecular Formula: C₁₅H₁₂N₆
• Molecular Weight: 276.29598
• Mol File: 746667-09-4.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: [1,2,4]Triazolo[1,5-a]pyridine, 6-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-(CAS DataBase Reference)
• NIST Chemistry Reference: [1,2,4]Triazolo[1,5-a]pyridine, 6-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-(746667-09-4)
• EPA Substance Registry System: [1,2,4]Triazolo[1,5-a]pyridine, 6-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-(746667-09-4)

Safety Data

• Hazardous Substances Data: 746667-09-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
[1,2,4]Triazolo[1,5-a]pyridine, 6-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]is used as a building block for the synthesis of novel bioactive molecules due to its unique molecular structure and potential biological activities.
Used in Medicinal Chemistry:
[1,2,4]Triazolo[1,5-a]pyridine, 6-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]is used as a lead compound for the development of new drugs, as its complex structure may contribute to the creation of innovative therapeutic agents.

Upstream product

• 614750-85-5 diphenyl (6-methylpyridin-2-yl)(phenylamino)methylphosphonate 
• 614750-82-2 1-(6-methylpyridin-2-yl)-2-[1,2,4]triazolo-[1,5-a]pyridin-6-yl-ethanone 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 614750-81-1 [1,2,4]-triazolo[1,5-a]pyridine-6-carbaldehyde 

Downstream Products

• 1338073-02-1 C₂₂H₁₅F₂N₇S 
• 1338072-89-1 C₂₃H₁₈N₈OS 
• 1338072-63-1 C₂₂H₁₆FN₇S 
• 1338072-93-7 C₂₂H₁₆ClN₇S 
• 1338072-81-3 C₂₃H₁₆F₃N₇S 
• 1338072-87-9 C₂₃H₁₆N₈S 
• 1338072-78-8 C₂₂H₁₆ClN₇S 
• 1338073-03-2 C₂₂H₁₅Cl₂N₇S 
• 1338073-00-9 C₂₂H₁₅F₂N₇S 
• 1338072-43-7 4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-(1-benzylpiperidin-4-yl)-3-(6-methylpyridin-2-yl)-1H-pyrazole-1-carbothioamide 
• 1338072-83-5 4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-(4-methoxyphenyl)-3-(6-methylpyridin-2-yl)-1H-pyrazole-1-carbothioamide 
• 1338072-76-6 C₂₂H₁₆FN₇S 
• 1338072-64-2 C₂₂H₁₆ClN₇S 
• 1338072-97-1 C₂₃H₁₉N₇OS 

Relevant articles and documents

4-([1,2,4]Triazolo[1,5-a]pyridin-6-yl)-5(3)-(6-methylpyridin-2-yl)imidazole and -pyrazole derivatives as potent and selective inhibitors of transforming growth factor-β type i receptor kinase

A series of 4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5(3)-(6-methylpyridin-2- yl)imidazoles and -pyrazoles 14a-c, 15a-c, 16a, 16b, 19a-d, 21a, and 21b has been synthesized and evaluated for their ALK5 inhibitory activity in an enzyme assay and in a cell-based luciferase reporter assay. Among them, the pyrazole derivative 21b inhibited ALK5 phosphorylation with an IC50 value of 0.018 μM and showed 95% inhibition at 0.03 μM in a luciferase reporter assay using HaCaT cells permanently transfected with p3TP-luc reporter construct. The 21b showed a high selectivity index of 284 against p38α MAP kinase. The binding pose of 21b generated by docking analysis reveals that it fits well into the ATP binding cavity of ALK5 by forming several hydrogen bond interactions.

Synthesis and biological evaluation of 1-substituted-3-(6-methylpyridin-2- yl)-4-([1,2,4triazolo[1,5-apyridin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors

A series of 1-substituted-3-(6-methylpyridin-2-yl)-4-([1,2,4triazolo[1,5- apyridin-6-yl)pyrazoles 14a-ae, 16a, 16b, and 21a-c has been prepared and evaluated for their ALK5 inhibitory activity in an enzyme assay and in a cell-based luciferase reporter ass

PYRAZOLES AND METHODS OF MAKING AND USING THE SAME

The invention is based on the discovery that compounds of formula I possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. In one embodiment, the invention features a compound of formula I (I).