7468-76-0

Upstream product

• 85-57-4 2-(4-hydroxy-benzoyl)-benzoic acid 
• 119-67-5 o-carboxybenzaldehyde 
• 108-95-2 phenol 
• 16859-59-9 3-hydroxy-1(3H)-isobenzofuranone 
• 86119-84-8 phosphoric acid 
• 643-79-8 o-phthalic dicarboxaldehyde 
• 14660-14-1 2-(4'-hydroxybenzyl)benzoic acid 
• 632340-63-7 2-[4'-hydroxy(bromobenzyl)]benzoic acid 

Downstream Products

• 37021-99-1 4-(3-oxohydroisobenzofuranyl)phenyl acetate 
• 120-12-7 anthracene 
• 21615-74-7 3-(4-methoxyphenyl)phthalide 
• 14660-14-1 2-(4'-hydroxybenzyl)benzoic acid 
• 1039045-96-9 C₂₃H₃₀O₃Si 
• 142717-68-8 1,3-bis-(4-hydroxy-phenyl)-isobenzofuran 

Relevant academic research and scientific papers

Near-infrared fluorophores containing benzo[c]heterocycle subunits

(Chemical Equation Presented) The syntheses and spectroscopic properties of eight new push-pull-type near-infrared fluorophores that contain either isobenzofuran or isothianaphthene subunits are presented. The isobenzofuran dyes demonstrate significantly red-shifted absorption compared with their isothianaphthene counterparts, which is attributed to isobenzofuran's more potent pro-quinoidal character.

Efficient synthesis of isobenzofuran-1(3H)-ones (Phthalides) and selected biological evaluations

The studies presented here deal with the convenient and efficient one-step conversion of o-alkylbenzoic acids into their corresponding isobenzofuran-1 (3H)-ones (phthalides) using NaBrO3/NaHSO3 in a two-phase system. A range of o-alkylbenzoic acids was used with the object of getting a variety of phthalide derivatives as multipurpose biologically active compounds. Seventeen phthalides have been synthesized and tested for cytotoxicity, antibacterial and antifungal activities. Some of these compounds showed promising cytotoxic effects against Artemia salina. Compounds 4j-4p were highly active against Gram-negative and Gram-positive bacteria among all tested compounds. In the fungicidal assay, the compounds showed a broad spectrum of activity against six fungi. All compounds were characterized via elemental analysis, UV, IR, mass and-NMR spectroscopy. ECV · Editio Cantor Verlag.

An alternative method for the synthesis of γ-lactones by using cesium fluoride-celite/acetonitrile combination

A variety of 2-(1-bromoalkyl) benzoic acids 4 undergo intramolecular nucleophilic substitution reaction when treated with a CsF-Celite as solid base in acetonitrile under reflux condition to give the corresponding cyclized phthalides in moderate to very good yield. These 2-(1-bromoalkyl) benzoic acids 4 are formed by the α-bromination of 2-alkylbenzoic acids 3 using N-bromosuccinimide and a catalytic amount of α,α′ -azoisobutyronitrile in carbon tetrachloride under reflux.

Indane-1,3-dione, Phthalimidine and Phthalide Derivatives as Alkylating Agents

The title compounds gave carbocations in acid media.The electrophilic aromatic substitution of those carbocations was studied.