7472-46-0

Basic information

• Product Name: 2-bromo-3-methylbutanamide
• CAS NO: 7472-46-0
• Molecular Formula: C₅H₁₀BrNO
• Molecular Weight: 180.043
• Mol File: 7472-46-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 247.9°C at 760 mmHg
• Flash Point: 103.7°C
• Density: 1.431g/cm³
• Vapor Pressure: 0.0251mmHg at 25°C
• Refractive Index: 1.49
• CAS DataBase Reference: 2-bromo-3-methylbutanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-3-methylbutanamide(7472-46-0)
• EPA Substance Registry System: 2-bromo-3-methylbutanamide(7472-46-0)

Safety Data

• Hazardous Substances Data: 7472-46-0(Hazardous Substances Data)

Upstream product

• 27109-47-3 2-bromoisovaleryl chloride 
• 7664-41-7 ammonia 
• 516-06-3 D,L-valine 
• 10323-40-7 2-bromoisovaleric acid 
• 503-74-2 3-methylbutyric acid 

Downstream Products

• 78-84-2 isobutyraldehyde 
• 29540-59-8 2-benzoyl-3-methyl-butyric acid amide 
• 181702-33-0 2-(4-Mercapto-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylsulfanyl)-3-methyl-butyramide 
• 911417-95-3 tert-butyl 5-(2-(3-(2-(isopropylamino)-2-oxoethoxy)phenyl)quinazolin-4-ylainino)-1H-indazole-1-carboxylate 
• 4026-18-0 2-hydroxy-3-methylbutanoic acid 
• 53153-78-9 (Cyano-isopropylmethylen)-cyclohexan 
• 93679-17-5 4-Amino-6-isopropyl-3-methylsulfanyl-1,6-dihydro-4H-[1,2,4]triazin-5-one 
• 181702-36-3 3-Methyl-2-(4-methylsulfanyl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylsulfanyl)-butyramide 
• 74-90-8 hydrogen cyanide 
• 10035-10-6 hydrogen bromide 

Relevant articles and documents

Synthesis of enantiomerically enriched-bromonitriles from amino acids

Two methods were investigated for the preparation of six chiral-bromonitriles with different optic purities. The nitrous deamination of amino acids gives-bromoacids, which react with chlorosulfonyl isocyanate followed by triethylamine to afford-bromonitriles with moderate enantiomeric excess. However, the dehydration of corresponding-bromoamids using thionyl chloride gives-bromonitriles with good enantiomeric excess up to 94%. The use of phosphoryl chloride instead of thionyl chloride results in more than 30% racemization as determined by high-performance liquid chromatograpic analysis.