7472-91-5Relevant academic research and scientific papers
N -alkynyl imides (ynimides): Synthesis and use as a variant of highly labile ethynamine
Sueda, Takuya,Oshima, Ayumi,Teno, Naoki
supporting information; experimental part, p. 3996 - 3999 (2011/10/01)
This study describes the first reliable synthesis of N-alkynyl imides (ynimides). This was accomplished with a copper-catalyzed coupling reaction between alkynyl(triaryl)bismuthonium salts and five-membered imides. We also found that it was possible to utilize N-ethynyl phthalimide as a variant of the highly labile ethynamine. 4-Amino-1,2,3-triazole was successfully obtained via the CuAAC reaction of N-ethynyl phthalimide with azide followed by hydrazinolysis of the phthaloyl protecting group.
Effect of substituents in the formation of diacetanilides
Ayyangar, Nagaraj R.,Srinivasan, Kumar V.
, p. 1292 - 1296 (2007/10/02)
A number of diacetanilides, including some which have not been reported so far, have been synthesized from the corresponding monoacetyl derivatives and characterized by spectral and elemental analyses.A tlc/fid method for the quantitative estimation of the relative amounts of mono- and diacetyl derivatives has been standardized.Linear correlation of the extent of diacetylation with Hammett ?-values of substituents and basicity constants of monoacetyl derivatives has been established.A plausible mechanism for the diacetylation reaction based on experimental observations has been suggested.An explanation for the anomalous behaviour of acetanilides containing electron-withdrawing substituents in the ortho-position has been put forth.
