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DIACETAMIDE, also known as N-Acetyl Acetamide, is a white crystalline powder or chunks with useful properties for organic synthesis. It is a versatile compound that finds applications in various industries due to its unique chemical properties.

625-77-4

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625-77-4 Usage

Uses

Used in Organic Synthesis:
DIACETAMIDE is used as a reagent for organic synthesis, facilitating the creation of a wide range of chemical compounds. Its ability to participate in various chemical reactions makes it a valuable component in the development of new materials and substances.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, DIACETAMIDE is used as an intermediate for the synthesis of various drugs. Its unique properties allow it to be a key component in the development of medications that target specific health conditions.
Used in Chemical Research:
DIACETAMIDE is also utilized in chemical research as a model compound to study various reaction mechanisms and to understand the behavior of similar compounds. This helps researchers in developing new synthetic methods and improving existing ones.
Used in Material Science:
In the field of material science, DIACETAMIDE is used as a building block for the development of new materials with specific properties. Its crystalline structure and chemical reactivity make it suitable for creating materials with tailored characteristics for various applications.

Purification Methods

Purify the amide by recrystallisation from MeOH [Arnett & Harrelson J Am Chem Soc 109 809 1987]. [Beilstein 2 H 181.]

Check Digit Verification of cas no

The CAS Registry Mumber 625-77-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,2 and 5 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 625-77:
(5*6)+(4*2)+(3*5)+(2*7)+(1*7)=74
74 % 10 = 4
So 625-77-4 is a valid CAS Registry Number.
InChI:InChI=1/C4H7NO2/c1-3(6)5-4(2)7/h1-2H3,(H,5,6,7)

625-77-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name N-acetylacetamide

1.2 Other means of identification

Product number -
Other names Acetamide,N-acetyl

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:625-77-4 SDS

625-77-4Relevant academic research and scientific papers

Si· O proximity in imidosilanes - Absence of orbital interactions

B?hme, Uwe,Herbig, Marcus,Kroke, Edwin

, (2021/11/09)

New N-silylated phthalimides, succinimides, and 1,8-napthalimides were synthesised by reactions of the alkali imides with chlorosilanes in THF. Six different mono-, di-, tri- and tetra-iminosilanes of the type (CH3)4-nSi(imide)n were obtained and the products analysed with 1H, 13C, 29Si NMR, and Raman spectroscopy. The molecular structures of four imidosilanes have been determined by single-crystal X-ray diffraction. A characteristic structural feature of the compounds is the fact that all intramolecular Si· O distances are significantly below the sum of the van-der-Waals radii of silicon and oxygen of 3.62 ?. Experimentally found values for Si· O distances range from 2.813 to 3.030 ?. However, there are no significant orbital interactions between silicon and oxygen atoms, as shown by quantum chemical analysis with AIM and NBO methods. The short Si· O distances in these molecules are caused by the geometry of the rigid imide group bound to the silicon atom, and there is no evidence for an increase of the coordination number of the Si atoms.

Synthesis of TiO2-Ag3PO4photocatalyst material with high adsorption capacity and photocatalytic activity: application in the removal of dyes and pesticides

Agyei-Tuffour, Benjamin,Efavi, Johnson K.,Manu, Gloria,Nyankson, Emmanuel

, p. 17032 - 17045 (2021/05/25)

The photocatalytic activity of TiO2can be enhanced by coupling it with other semiconductors and the semiconductor composites may find useful application in water treatment technologies. TiO2-Ag3PO4composites wer

Heterolytic (2 e) vs Homolytic (1 e) Oxidation Reactivity: N?H versus C?H Switch in the Oxidation of Lactams by Dioxirans

Annese, Cosimo,D'Accolti, Lucia,Fusco, Caterina,Licini, Giulia,Zonta, Cristiano

supporting information, p. 259 - 262 (2017/01/17)

Dioxiranes are powerful oxidants that can act via two different mechanisms: 1) homolytic (H abstraction and oxygen rebound) and 2) heterolytic (electrophilic oxidation). So far, it has been reported that the nature of the substrate dictates the reaction mode independently from the dioxirane employed. Herein, we report an unprecedented case in which the nature of the dioxirane rules the oxidation chemoselectivity. In particular, a switch from C?H to N?H oxidation is observed in the oxidation of lactams moving from dimethyl dioxirane (DDO) to methyl(trifluoromethyl)dioxirane (TFDO). A physical organic chemistry study, which combines the oxidation with two other dioxiranes methyl(fluoromethyl)dioxirane, MFDO, and methyl(difluoromethyl)dioxirane, DFDO, with computational studies, points to a diverse ability of the dioxiranes to either stabilize the homo or the heterolytic pathway.

A mild, aromatization of cyclic compounds and oxidation of amino groups to carbonyls using o-iodoxybenzoic acid

Kacan,Cicek,Karabulut,Ozyildirim

, p. 7649 - 7650 (2013/08/23)

A new, mild and efficient method has been developed for the synthesis of aromatic compounds and some carbonyls via the oxidative aromatization of amino cyclic compound by using hypervalent iodine reagent in DMSO at ambient temperature. The facile synthetic accessibility and it is as mild as non-hazardous nature render o-iodoxybenzoic acid equivalent of Dess-Martin periodinane reagent in organic oxidations.

Synthesis of 1,3,5-trisubstituted-1,2,4-triazoles by microwave-assisted N-acylation of amide derivatives and the consecutive reaction with hydrazine hydrochlorides

Lee, Jongbok,Hong, Myengchan,Jung, Yoonchul,Cho, Eun Jin,Rhee, Hakjune

experimental part, p. 2045 - 2051 (2012/04/10)

Facile and efficient procedures for the N-acylation reaction of amide derivatives with various acid anhydrides and the cyclization reaction of N-acylated amide derivatives with various hydrazine hydrochlorides were described. The reactions were carried out under microwave irradiation to give products in good yields in a few minutes. The synthesis of 1,3,5-trisubstituted- 1,2,4-triazoles from benzamides can also be accomplished in a simple one-pot sequential reaction.

N-Butylammonium carboxylates/Tf2O: Ionic liquid based systems for the synthesis of unsymmetrical imides via a Ritter-type reaction

Khodaei, Mohammad Mehdi,Nazari, Ehsan

experimental part, p. 2881 - 2884 (2012/07/28)

We have developed a new method for the preparation of unsymmetrical imides using liquid carboxylate salts via a Ritter-type process. The reactions were carried out with nitriles and n-butylammonium carboxylates as ionic liquids in the presence of triflic anhydride (Tf2O) as the promoter. Mild reaction conditions, simplicity of the procedure, and proton-free conditions are the main advantages of this procedure.

Ultrasound-assisted catalytic synthesis of acyclic imides in the presence of p-toluenesulfonic acid under solvent-free conditions

Nasr-Esfahani, Masoud,Montazerozohori, Morteza,Filvan, Najmeh

experimental part, p. 415 - 421 (2012/06/29)

A rapid and convenient preparation of acyclic imides by the reaction of aliphatic and aromatic nitriles with acyclic carboxylic anhydride in the presence of catalytic amounts of p-toluenesulfonic acid under thermal or ultrasonic conditions is reported. The advantages of this procedure are moderate reaction times, good to excellent yields, and use of an inexpensive and ecofriendly catalyst. The reaction of nitriles with aliphatic anhydrides proceeds under thermal conditions, while they are accelerated by the use of ultrasound irradiation.

Efficient synthesis of symmetrical and unsymmetrical acyclic imides catalyzed by reusable 12-tungstophosphoric acid under thermal conditions and microwave irradiation

Mohammadpoor-Baltork,Tangestaninejad,Moghadam,Mirkhani,Nasr-Esfahani

experimental part, p. 401 - 410 (2012/06/16)

An efficient and environmentally friendly procedure has been developed for the synthesis of symmetrical and unsymmetrical acyclic imides by the reaction of nitriles with acyclic anhydrides in the presence of catalytic amounts of 12-tungstophosphoric acid (H3PW12O40) under thermal conditions and microwave irradiation. It was found that microwave improves the yields and significantly reduces the reaction times. Furthermore, the catalyst could be recovered and reused several times without decrease in its activity.

A simple synthesis of imide-dipeptides

Ke, Damei,Zhan, Chuanlang,Li, Xiao,Li, Alexander D. Q.,Yao, Jiannian

body text, p. 1506 - 1510 (2009/12/24)

We report a simple approach to synthesize a new class of imide-dipeptides. This approach is mild, and the starting materials are the easily accessible amino acid derivatives. The imide-dipeptides were synthesized from the coupling of an amide and a 4-nitrophenyl activating ester of an amino acid. The acidic proton of the first amide was removed by 1 equivalent of n-butyl lithium to afford the corresponding amide anion which then reacted with the activating ester to give the desired imide derivatives. Georg Thieme Verlag Stuttgart.

A novel one-pot synthesis of unsymmetrical acyclic imides

Habibi, Zohreh,Salehi, Peyman,Zolfigol, Mohammad Ali,Yousefi, Maryam

, p. 812 - 814 (2008/01/03)

A new and convenient method was found for the one-pot synthesis of symmetrical and unsymmetrical linear imides by reaction of aliphatic and aromatic nitriles with acyclic carboxylic anhydrides in the presence of silica sulfuric acid as an active and recyclable reagent. Georg Thieme Verlag Stuttgart.

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