74720-35-7

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 30166-29-1 1-acetyl-3-[(Z)-benzylidene]-2,5-piperazinedione 
• 3027-05-2 N,N'-diacetylpiperazin-2,5-dione 
• 100-52-7 benzaldehyde 
• 123-11-5 4-methoxy-benzaldehyde 
• 53736-74-6 (3z)-1-Acetyl-3-(4-methoxybenzylidene)-2,5-piperazinedione 
• 30166-29-1 1-acetyl-3-benzylidene-2,5-piperazinedione 
• 19459-03-1 (Z)-3-phenylmethylenepiperazine-2,5-dione 

Downstream Products

• 30166-29-1 1-acetyl-3-benzylidene-2,5-piperazinedione 

Relevant academic research and scientific papers

Ir-Catalyzed Double Asymmetric Hydrogenation of 3,6-Dialkylidene-2,5-diketopiperazines for Enantioselective Synthesis of Cyclic Dipeptides

An Ir/spiro[4,4]-1,6-nonadiene-based phosphine-oxazoline ligand (SpinPHOX) complex-catalyzed double asymmetric hydrogenation of 3,6-dialkylidene-1,4-dimethylpiperazine-2,5-diones has been developed, providing efficient and practical access to a wide varie

Phenotype-Guided Natural Products Discovery Using Cytological Profiling

Phenotype-guided natural products discovery is emerging as a useful new discovery tool that addresses challenges in early, unbiased natural product biological annotation. These high-content approaches yield screening results that report directly on the im

Solution-phase combinatorial synthesis and evaluation of piperazine-2,5- dione derivatives

An efficient one-pot synthesis of a 61-membered combinatorial chemistry library of piperazine-2,5-diones was accomplished. Results of combinatorial synthesis, purification, analysis, and biological evaluation are described.

Pharmaceutical compounds

Piperazine derivatives of the formula STR1 their esters and salts are useful as modulators of multiple drug resistance.

Pharmaceutical piperazine compounds

Diketopiperazines of formula (A): STR1 wherein each of R1 to R8 is H or an organic radical as described herein and the pharmaceutically acceptable salts thereof have activity as inhibitors of plasminogen activator inhibitor.

Pharmaceutical piperazine compounds

Piperazine derivatives of formula (A): STR1 wherein -------- denotes an optional bond, provided that either ----a---- and ----c---- are both bonds and ----b

Pharmaceutical compounds

Diketopiperazines of the formula: STR1 where each of R1 to R10, which may be the same or different, is independently selected from the group consisting of hydrogen, C1 -C6 alkyl unsubstituted or substituted by o

Inhibition of plasminogen activator inhibitor-1 activity by two diketopiperazines, XR330 and XR334 produced by Streptomyces sp.

Two diketopiperazines, XR334 (1) and the novel compound XR330 (2), were isolated from the lyophilised biomass of an unidentified Streptomyces sp. Their structures were elucidated on the basis of spectroscopic studies and confirmed by chemical synthesis. B

Potassium Fluoride on Alumina: Condensation of 1,4-Diacetylpiperazine-2,5-dione with Aldehydes. Dry Condensation under Microwave Irradiation. Synthesis of Albonursin and Analogues

1,4-Diacetylpiperazine-2,5-dione (1) was condensated with aldehydes (2) with KF on alumina without solvent under microwaves or in at room temperature in the presence of DMF.The reaction was stereoselective and some natural products (4a-c) like albonursin (4c) were synthesized.

α,β-Unsaturated Carboxylic Acid Derivatives. Part 18. Syntheses of Geometric Isomers of 3,6-Dibenzylidene- and 3-p-Anisylidene-6-benzylidene-2,5-piperazinediones

Naturally occuring 3,6-dibenzylidene- and 3-p-anisylidene-6-benzylidene-2,5-piperazinediones and their geometric isomers were synthesized by the condensation of 1-acetyl or 1,4-diacetyl derivative of (E)- and (Z)-benzylidene- or p-anisylidene-2,5-piperazinediones with an appropriate aldehyde.The configuration of these compounds were assigned on the basis of the spectroscopic analyses, and those of natural products were determined to be (3Z,6Z).