74738-21-9Relevant academic research and scientific papers
Scope of the organocatalysed asymmetric reductive amination of ketones with trichlorosilane
Gautier, Franois-Moana,Jones, Simon,Li, Xianfu,Martin, Stephen J.
experimental part, p. 7860 - 7868 (2011/12/02)
A highly active organocatalyst has been shown to affect the asymmetric reductive amination of ketones producing both aromatic and aliphatic amines. At 1 mol% catalyst loading, a series of structurally diverse chiral amines were quickly and economically prepared with good enantioselectivity and generally useful yield. The efficient synthesis of the calcimimetic (+)-NPS R-568 (67%, 89% ee) demonstrated the synthetic applicability of this methodology.
Heterocyclic compounds
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Page/Page column 12, (2010/02/14)
The inventive subject matter relates to compounds, pharmaceutical compositions, and kits containing a heterocyclic compound represented by the formula (I) wherein R is an alkyl group optionally having substituent(s) etc., X is an amino group optionally having substituent(s), Y1 and Y2 are nitrogen atoms etc., an isomer or solvate thereof or a pharmaceutically acceptable salt thereof as an active ingredient.
STEREOCHEMISTRY OF THE DEALKOXYCARBONYLATION OF METHYL Α-CYANOCINNAMATE AND OF THE DECARBOXYLATION OF THE CORRESPONDING CYANOACID: A FACILE STEREOSELECTIVE ROUTE TO Z-CINNAMONITRILE
Babler, James H.,Spina, Kenneth P.
, p. 3835 - 3838 (2007/10/02)
Decarboxylation of E-3-phenyl-2-cyanopropenoic acid (1) in dimethyl sulfoxide containing sodium bicarbonate, lithium chloride, and water in molar excess afforded, with high stereospecifity, Z-cinnamonitrile (6).The dealkoxycarbonylation of the corresponding methyl ester (2) under similar reaction conditions was much less selective and resulted in a 1:1 mixture of E- and Z- stereoisomeric nitriles (6 and 7).
