7474-97-7

Basic information

• Product Name: 4-Hydroxy-1-naphthoic acid
• Synonyms: 4-Hydroxy-1-naphthoic acid;1-Naphthalenecarboxylicacid, 4-hydroxy-;4-Hydroxy-naphthalene-1-carboxylic acid
• CAS NO: 7474-97-7
• Molecular Formula: C₁₁H₈O₃
• Molecular Weight: 188.17942
• Mol File: 7474-97-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: 183-184 °C
• Boiling Point: 442.2°Cat760mmHg
• Flash Point: 235.4°C
• Appearance: /
• Density: 1.399g/cm³
• Vapor Pressure: 1.35E-08mmHg at 25°C
• Refractive Index: 1.716
• PKA: 4.34±0.10(Predicted)
• CAS DataBase Reference: 4-Hydroxy-1-naphthoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hydroxy-1-naphthoic acid(7474-97-7)
• EPA Substance Registry System: 4-Hydroxy-1-naphthoic acid(7474-97-7)

Safety Data

• Hazardous Substances Data: 7474-97-7(Hazardous Substances Data)

Usage

General Description

4-Hydroxy-1-naphthoic acid, also known as 4-hydroxy-1-naphthoic acid or 1-hydroxy-4-naphthoic acid, is an organic compound with the formula C11H8O3. It is a derivative of naphthoic acid and is a white to light yellow crystalline solid. 4-Hydroxy-1-naphthoic acid is primarily used as a dye intermediate in the production of azo dyes and pigments, and in the manufacture of pharmaceuticals. It is also used in organic synthesis and as a precursor for the production of other chemicals. 4-Hydroxy-1-naphthoic acid is considered to be relatively low in toxicity and does not pose significant environmental or health risks when handled and used properly.

InChI:InChI=1/C11H8O3/c12-10-6-5-9(11(13)14)7-3-1-2-4-8(7)10/h1-6,12H,(H,13,14)

Upstream product

• 64-18-6 formic acid 
• 91-20-3 naphthalene 
• 90-15-3 α-naphthol 
• 124-38-9 carbon dioxide 
• 86-55-5 1-naphthalenecarboxylic acid 

Downstream Products

• 3651-02-3 4-Phenylazo-1-naphthol 
• 165185-23-9 3-amino-4-hydroxy-[1]naphthoic acid 
• 21905-89-5 4-Carboxy-1,2-naphthochinon 
• 27828-56-4 4-(phenylamino)naphthalene-1,2-dione 
• 571-57-3 4-bromo-1-naphthol 

Relevant articles and documents

Redox-Neutral Photocatalytic C?H Carboxylation of Arenes and Styrenes with CO2

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Hydroxylation of ionized aromatics including carboxylic acid or amine using recombinant Streptomyces lividans cells expressing modified biphenyl dioxygenase genes

The bphA1(2072)A2A3A4 gene cluster codes for a shuffled biphenyl dioxygenase holoenzyme with broad substrate specificity. These bphA1(2072)A2A3A4 genes were expressed in the actinomycetes Streptomyces lividans using a thiostrepton-inducible promoter PtipA. Biotransformation experiments of various aromatics including carboxylic acid or amine in their molecular structure, such as 1-naphthoic acid, 2-(1-naphthyl)acetic acid, diphenylamine, and 1-benzyl-4-piperidone, were performed using the recombinant S.lividans cells. These ionized aromatics were converted to the corresponding 1,2-dihydrodiol, mono- or tri-hydroxy forms in 48h. The structure of the converted products was determined by their EI-MS, 1H- and 13C NMR analysis, and several products were found to be novel compounds.