7474-97-7

Usage

Uses

Used in Dye Industry:
4-Hydroxy-1-naphthoic acid is used as a dye intermediate for the production of azo dyes and pigments. It plays a crucial role in the synthesis of various dyes and pigments, contributing to the coloration and appearance of textiles, plastics, and other materials.
Used in Pharmaceutical Industry:
4-Hydroxy-1-naphthoic acid is used as a starting material in the manufacture of pharmaceuticals. Its unique chemical structure allows it to be a valuable component in the development of new drugs and medications.
Used in Organic Synthesis:
4-Hydroxy-1-naphthoic acid is used as a precursor in organic synthesis, enabling the creation of a wide range of chemical compounds for various applications across different industries.
Used in Chemical Production:
4-Hydroxy-1-naphthoic acid serves as a precursor for the production of other chemicals, further expanding its utility and applications in the chemical industry.

InChI:InChI=1/C11H8O3/c12-10-6-5-9(11(13)14)7-3-1-2-4-8(7)10/h1-6,12H,(H,13,14)

Upstream product

• 86-55-5 1-naphthalenecarboxylic acid 
• 90-15-3 α-naphthol 
• 124-38-9 carbon dioxide 
• 64-18-6 formic acid 
• 91-20-3 naphthalene 

Downstream Products

• 3651-02-3 4-Phenylazo-1-naphthol 
• 165185-23-9 3-amino-4-hydroxy-[1]naphthoic acid 
• 21905-89-5 4-Carboxy-1,2-naphthochinon 
• 27828-56-4 4-(phenylamino)naphthalene-1,2-dione 
• 571-57-3 4-bromo-1-naphthol 

Relevant academic research and scientific papers

Palladium(II)-catalyzed sequential hydroxylation-carboxylation of biphenyl using formic acid as a carbonyl source

(Equation Presented) A simultaneous hydroxylation-carboxylation of biphenyl occurred to give 4′-hydroxy-4-biphenylcarboxylic acid, which has wide potential application as a polyester monomer.

Hydroxylation of ionized aromatics including carboxylic acid or amine using recombinant Streptomyces lividans cells expressing modified biphenyl dioxygenase genes

The bphA1(2072)A2A3A4 gene cluster codes for a shuffled biphenyl dioxygenase holoenzyme with broad substrate specificity. These bphA1(2072)A2A3A4 genes were expressed in the actinomycetes Streptomyces lividans using a thiostrepton-inducible promoter PtipA. Biotransformation experiments of various aromatics including carboxylic acid or amine in their molecular structure, such as 1-naphthoic acid, 2-(1-naphthyl)acetic acid, diphenylamine, and 1-benzyl-4-piperidone, were performed using the recombinant S.lividans cells. These ionized aromatics were converted to the corresponding 1,2-dihydrodiol, mono- or tri-hydroxy forms in 48h. The structure of the converted products was determined by their EI-MS, 1H- and 13C NMR analysis, and several products were found to be novel compounds.