74864-94-1

Basic information

• Product Name: N₁-(2-chlorophenyl)benzene-1,2-diamine
• Synonyms: N₁-(2-chlorophenyl)benzene-1,2-diamine
• CAS NO: 74864-94-1
• Molecular Weight: 218.686
• Mol File: 74864-94-1.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: N₁-(2-chlorophenyl)benzene-1,2-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: N₁-(2-chlorophenyl)benzene-1,2-diamine(74864-94-1)
• EPA Substance Registry System: N₁-(2-chlorophenyl)benzene-1,2-diamine(74864-94-1)

Safety Data

• Hazardous Substances Data: 74864-94-1(Hazardous Substances Data)

Upstream product

• 95-51-2 o-chloroaniline 
• 1493-27-2 ortho-nitrofluorobenzene 
• 53445-01-5 5-methoxy-2,3,8,9-tetrahydro-1H-cyclopentanaphthalen-7(6H)-one 
• 74002-26-9 N-(2-chlorophenyl)-N-(2-nitrophenyl)amine 
• 88-74-4 2-nitro-aniline 
• 694-80-4 2-bromo-1-chlorobenzene 
• 95-54-5 1,2-diamino-benzene 
• 95-50-1 1,2-dichloro-benzene 

Downstream Products

• 124290-39-7 1,5-bis-(2-chloro-phenyl)-2,2-dimethyl-2,5-dihydro-1H-imidazo[4,5-b]phenazine 
• 1033225-66-9 1-(2-chlorophenyl)-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide 
• 613-32-1 5,10-dihydrophenazine 
• 92-82-0 Phenazin 
• 116031-14-2 2-(2-chloro-anilino)-5-(2-chloro-phenyl)-3-isopropylamino-phenazinium-betaine 
• 2622-67-5 1,2-diphenyl-1H-benzoimidazole 
• 81568-76-5 1-(2-chlorophenyl)-2-phenyl-1H-benzo[d]imidazole 
• 104093-42-7 1-(2-chlorophenyl)-1H-benzo[d][1,2,3]triazole 

Relevant articles and documents

ORGANIC ELECTROLUMINESCENT COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING THE SAME

The present application relates to an organic electroluminescent compound represented by chemical formula 1, and an organic electroluminescent device comprising the same. By comprising the organic electroluminescent compound of the present application having good thermal stability, it is possible to provide the organic electroluminescent device having lower driving voltage, high luminous efficiency and/or long lifespan characteristics compared with an existing organic electroluminescent device.COPYRIGHT KIPO 2020

Design, synthesis and biological evaluation of novel 4-phenoxyquinoline derivatives containing 3-oxo-3,4-dihydroquinoxaline moiety as c-Met kinase inhibitors

A series of novel 4-phenoxyquinoline derivatives containing 3-oxo-3,4-dihydroquinoxaline moiety were synthesized and evaluated for their c-Met kinase inhibitory activity and antiproliferative activity against five cancer cell lines (HT-29, H460, A549, MKN-45 and U87MG) in vitro. Most of the compounds exhibited moderate-to-significant cytotoxicity as compared with foretinib. The most promising compound 41 (with c-Met IC50 value of 0.90?nM) showed remarkable cytotoxicity against HT-29, H460, A549, MKN-45 and U87MG cell lines with IC50 values of 0.06?μM, 0.05?μM, 0.18?μM, 0.023?μM and 0.66?μM, respectively, and thus it was 1.22- to 3.50-fold more potent than foretinib. Their preliminary structure-activity relationships (SARs) studies indicate that electron-withdrawing groups on the terminal phenyl rings are beneficial for improving the antitumor activity.

Palladium-catalyzed domino double n-arylations (inter- and intramolecular) of 1,2-diamino(hetero)arenes with o,o-dihalo(hetero)arenes for the synthesis of phenazines and pyridoquinoxalines

Domino reactions for the synthesis of phenazines have been developed that start from 1,2-diaminoarenes and 1,2-dihaloarenes and proceed through palladium-catalyzed double N-arylations (inter- and intramolecular) followed by an in situ oxidation. A variety of functional groups, which include base-sensitive groups, were well tolerated under the optimized reaction conditions to afford phenazines in good to excellent yields. The protocol was extended to the synthesis of pyridoquinoxalines by employing either o-phenylenediamines and 2,3-dihalopyridines or 1,2-diaminopyridines and 1,2-dihaloarenes. Domino reactions for the synthesis of phenazines have been developed that start from 1,2-diaminoarenes and 1,2-dihaloarenes and proceed through palladium-catalyzed double N-arylations (inter- and intramolecular) followed by an in situ oxidation. The protocol was extended to the synthesis of pyridoquinoxalines. Copyright