749861-39-0Relevant articles and documents
Stereocontrolled total synthesis of (±)-FR901483
Ieda, Shigeru,Asoh, Yusuke,Fujimoto, Teppei,Kitaoka, Haruka,Kan, Toshiyuki,Fukuyama, Tohru
experimental part, p. 721 - 738 (2009/12/26)
The total synthesis of potent immunosuppressant FR901483 (1) is reported. The remarkable feature of our convergent synthesis is the p-methoxybenzyl and methylamino groups are stereoselectively incorporated within the tri-cyclic core skeleton. The skeleton
Stereocontrolled total synthesis of potent immunosuppressant FR901483
Kan, Toshiyuki,Fujimoto, Teppei,Ieda, Shigeru,Asoh, Yusuke,Kitaoka, Haruka,Fukuyama, Tohru
, p. 2729 - 2731 (2007/10/03)
A total synthesis of the potent immunosuppressant FR901483 (1) has been accomplished. The key feature of our convergent synthesis is the stereoselective incorporation of the p-methoxybenzyl and methylamino groups within the core moiety 10. Tricycle 10 was
