7505-93-3

Basic information

• Product Name: 2-Cyano-2-MethylpropanaMide
• Synonyms: 2-Cyano-2-MethylpropanaMide
• CAS NO: 7505-93-3
• Molecular Formula: C₅H₈N₂O
• Molecular Weight: 112.12982
• Mol File: 7505-93-3.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 285.1°C at 760 mmHg
• Flash Point: 126.2°C
• Appearance: /
• Density: 1.064g/cm³
• Vapor Pressure: 0.00287mmHg at 25°C
• Refractive Index: 1.456
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-Cyano-2-MethylpropanaMide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Cyano-2-MethylpropanaMide(7505-93-3)
• EPA Substance Registry System: 2-Cyano-2-MethylpropanaMide(7505-93-3)

Safety Data

• Hazardous Substances Data: 7505-93-3(Hazardous Substances Data)

Usage

General Description

2-Cyano-2-MethylpropanaMide, also known as tert-Butylcyanamide, is a chemical compound with the molecular formula C5H9N3. It is a colorless liquid with a strong ammonia-like odor. 2-Cyano-2-MethylpropanaMide is primarily used as an intermediate in the production of pharmaceuticals and agrochemicals. It is also used as a chemical reagent in organic synthesis to introduce the cyano group into organic molecules. Additionally, it has been investigated for its potential use in the treatment of type 2 diabetes and other metabolic disorders due to its ability to activate peroxisome proliferator-activated receptor gamma (PPARγ), a target for antidiabetic drugs. However, it is important to handle 2-Cyano-2-MethylpropanaMide with caution, as it is considered a hazardous substance and can cause irritation to the skin, eyes, and respiratory system.

InChI:InChI=1/C5H8N2O/c1-5(2,3-6)4(7)8/h1-2H3,(H2,7,8)

Upstream product

• 22426-30-8 2-cyano-2-methylpropanoic acid 
• 1572-98-1 2-cyano-2-methyl-propionic acid ethyl ester 
• 72291-30-6 methyl 2,2-dimethyl-cyanoacetate 
• 86439-20-5 2,2-dimethyl-3-oximinoadipamide 
• 107-91-5 cyanoacetic acid amide 
• 74-88-4 methyl iodide 

Downstream Products

• 666844-61-7 (2-carbamoyl-2-methylpropyl)carbamic acid benzyl ester 
• 173334-58-2 (2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxypropyl)-4-hydroxy-7-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-8-methyl-(2-propan-2-yl)nonanamide hemifumarate 
• 324763-47-5 (2S,4S,5S,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(methoxypropoxy)benzyl)-8-methylnonanamide 
• 77-71-4 5,5-dimethyl-imidazolidine-2,4-dione 
• 7321-55-3 2,2-dimethylmalononitrile 
• 20762-07-6 2-Cyan-2-methyl-propionsaeure-dianilinophosphorylamid 
• 173334-57-1 (2S,4S,5S,7S)-5-Amino-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-8-methyl-nonanoic acid (2-carbamoyl-2-methyl-propyl)-amide 
• 324763-51-1 aminopivalinamide 
• 173338-07-3 tert-butyl (3S,5S,6S,8S)-8-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-6-hydroxy-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-2,9-dimethyldecan-5-ylcarbamate 

Relevant articles and documents

FUMAGILLOL COMPOUNDS AND METHODS OF MAKING AND USING SAME

Disclosed herein, in part, are fumagillol compounds and methods of use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making fumagillol compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.

N-Acyl-N'-(pyridin-2-yl) Ureas and Analogs Exhibiting Anti-Cancer and Anti-Proliferative Activities

Described are compounds of Formula I which find utility in the treatment of cancer, autoimmune diseases and metabolic bone disorders through inhibition of c-FMS (CSF-1R), c-KIT, and/or PDGFR kinases. These compounds also find utility in the treatment of other mammalian diseases mediated by c-FMS, c-KIT, or PDGFR kinases.

PROCESS FOR THE PREPARATION OF (2S,4S,5S,7S)-N-(2-CARBAMYL-2- METHYLPROPYL)-5-AMINO-4-HYDROXY-2,7-DIISOPROPYL-8-[4-METHOXY-3-(3- METHOXYPROPOXY)PHENYL]-OCTANAMIDE HEMIFUMARATE AND ITS INTERMEDIATES THEREOF

The present invention relates to a process for the preparation of (2S,4S,5S,7S)-N-(2- Carbamoyl-2-methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3-methoxy propoxy )phenyl]-octanamide compound of formula- 1 and its pharmaceutically acceptable salts thereof. Further, relates to the processes for the preparation of (R)-4-(2-(halomethyl)-3- methylbutyl)-l-methoxy-2-(3-methoxypropoxy) benzene and (R)-2-(4-methoxy-3-(3-methoxy propoxy) benzyl)-3-methyIbutan-l-ol useful intermediates in the synthesis of compound of formula- 1.