22426-30-8

Usage

Uses

Used in Pharmaceutical Industry:
2-Cyano-2-methylpropanoic acid serves as a key building block in the synthesis of pharmaceuticals, contributing to the development of new medications due to its unique chemical structure and reactivity.
Used in Agrochemical Industry:
In the agrochemical sector, 2-cyano-2-methylpropanoic acid is utilized as an intermediate in the production of various agrochemicals, playing a role in the creation of compounds that can enhance crop protection and yield.
Used in Dye and Pigment Production:
2-Cyano-2-methylpropanoic acid is employed as a starting material in the synthesis of dyes and pigments, where its chemical properties allow for the development of a wide range of colorants used in different industries.
Used in Organic Compound Synthesis:
Beyond its applications in specific industries, 2-cyano-2-methylpropanoic acid is a versatile compound used in the synthesis of other organic compounds, broadening its utility in chemical research and development.

InChI:InChI=1/C5H7NO2/c1-5(2,3-6)4(7)8/h1-2H3,(H,7,8)

Upstream product

• 1572-98-1 2-cyano-2-methyl-propionic acid ethyl ester 
• 36559-87-2 3-hydroxy-2,2-dimethylpropionaldoxime 
• 105-56-6 ethyl 2-cyanoacetate 
• 74-88-4 methyl iodide 
• 72291-30-6 methyl 2,2-dimethyl-cyanoacetate 
• 124-38-9 carbon dioxide 
• 126-98-7 methacrylonitrile 
• 14618-77-0 methyl 2-cyanopropionate 
• 41296-71-3 3-acetoxy-2,2-dimethyl-propionitrile 
• 19295-57-9 3-hydroxy-2,2-dimethylpropionitrile 
• 7321-55-3 2,2-dimethylmalononitrile 

Downstream Products

• 84213-57-0 N-(1-cyano-1-methylethyl)-2-methylpropanamide 
• 1001076-91-0 C₁₉H₁₉N₃O₄S 
• 19295-57-9 3-hydroxy-2,2-dimethylpropionitrile 
• 78-82-0 Isobutyronitrile 
• 120511-72-0 3,5-bis(2-cyanoprop-2-yl)toluene 
• 7505-93-3 2-cyano-2-methylpropanamide 
• 881417-72-7 N-(4-{[[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl](methyl)amino]sulfonyl}phenyl)-2-cyano-2-methylpropanamide 

Relevant academic research and scientific papers

Potassium trimethylsilanolate-mediated conversion of dialkyl phosphonates to their anhydrous potassium monoalkyl phosphonates under mild, non-aqueous conditions

Anhydrous potassium monoalkyl phosphonates have been prepared from the corresponding dialkyl phosphonates and potassium trimethylsilanolate under non-aqueous conditions in good to excellent yields. Simple workup procedure has been developed to afford high purity products.

OXADIAZOLE COMPOUNDS

Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for treating cancers. Specific cancers include those that are mediated by YAP/TAZ or those that are modulated by the interaction between YAP/TAZ and TEAD.

NAPHTHYRIDINES AS INHIBITORS OF HPK1

Naphthyridine compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the naphthyridine compounds.

Construction of a visible light-driven hydrocarboxylation cycle of alkenes by the combined use of Rh(i) and photoredox catalysts

A visible light driven catalytic cycle for hydrocarboxylation of alkenes with CO2 was established using a combination of a Rh(i) complex as a carboxylation catalyst and [Ru(bpy)3]2+ (bpy = 2,2′- bipyridyl) as a photoredox catalyst. Two key steps, the generation of Rh(i) hydride species and nucleophilic addition of π-benzyl Rh(i) species to CO2, were found to be mediated by light.

Palladium-Catalyzed Direct Arylation of C(sp3)-H Bonds of α-Cyano Aliphatic Amides

Pd(OAc)2-catalyzed arylation of C(sp3)-H bonds in α-cyano-α-methyl aliphatic amides is achieved in the presence of 8-aminoquinoline, as a removable directing group, using Mn(OAc)2 and Na2CO3. The current strategy enables the placement of an aryl/heteroaryl group at the β-position of α-cyano aliphatic acids for the first time. Wide functional group tolerance and easily accessible starting materials provide an efficient protocol for the synthesis of arylated α-cyano amides. Furthermore, the synthetic utility of the products has been demonstrated by their efficient conversions to medicinally important α,α-dialkylated acid and β-amino acid derivatives.

N-Acyl-N'-(pyridin-2-yl) Ureas and Analogs Exhibiting Anti-Cancer and Anti-Proliferative Activities

Described are compounds of Formula I which find utility in the treatment of cancer, autoimmune diseases and metabolic bone disorders through inhibition of c-FMS (CSF-1R), c-KIT, and/or PDGFR kinases. These compounds also find utility in the treatment of other mammalian diseases mediated by c-FMS, c-KIT, or PDGFR kinases.

MELANOCORTIN RECEPTOR AGONISTS

The present invention relates to a compound of the following formula 1, pharmaceutically acceptable salt and isomer thereof effective as agonist of melanocortin receptor, and an agonistic composition of melanocortin receptor comprising the same as active ingredient.

Nitrilase-catalyzed selective hydrolysis of dinitriles and green access to the cyanocarboxylic acids of pharmaceutical importance

To further explore its synthetic applications, the nitrilase bll6402 from Bradyrhizobium japonicum strain USDA110 has been examined toward the hydrolysis of various dinitriles. It has been found that nitrilase bll6402 effectively hydrolyzed α,ω-dinitriles to ω-cyanocarboxylic acids, and the selectivity was independent of the substrate chain length. This feature is distinct from all the known nitrilases of various sources. Nitrilase bll6402 was thus applied to the synthesis of 1-cyanocycloalkaneacetic acids, the useful precursors for the synthesis of gabapentin and its analogues.

Exploring the synthetic applicability of a cyanobacterium nitrilase as catalyst for nitrile hydrolysis

The substrate specificity and synthetic applicability of the nitrilase from cyanobacterium Synechocystis sp. strain PCC 6803 have been examined. This nitrilase catalyzed the hydrolysis of both aromatic and aliphatic nitriles to the corresponding acids in high yields. Furthermore, the stereoselective hydrolysis of phenyl-substituted β-hydroxy nitriles to (S)-enriched β-hydroxy carboxylic acids and selective hydrolysis of α,ω- dinitriles with five or less methylene groups to ω-cyano carboxylic acids have been achieved. This suggested that nitrilase from Synechocystis sp. PCC 6803 could be a useful enzyme catalyst for the "green" nitrile hydrolysis. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.

PYRIMIDINEDIONE, PYRIMIDINETRIONE, TRIAZINEDIONE AND TETRAHYDROQUINAZOLINEDIONE DERIVATIVES AS ALPHA1-ADRENERGIC RECEPTOR ANTAGONISTS

Compounds of Formula I: STR1 where R 5 is a group selected from Formulae (a), (b), (c) and (d): STR2 and the pharmaceutically acceptable salts and N-oxides thereof, are α 1-adrenergic receptor antagonists useful for the treatment of diseases involving directly or indirectly an obstruction of the lower urinary tract, such as benign prostatic hyperplasia.