75135-46-5

Basic information

• Product Name: N2-Methylpyridine-2,6-diaMine
• Synonyms: N2-Methylpyridine-2,6-diaMine;2,6-PYRIDINEDIAMINE,N-METHYL
• CAS NO: 75135-46-5
• Molecular Formula: C₆H₉N₃
• Molecular Weight: 123.15576
• EINECS: -0
• Mol File: 75135-46-5.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N2-Methylpyridine-2,6-diaMine(CAS DataBase Reference)
• NIST Chemistry Reference: N2-Methylpyridine-2,6-diaMine(75135-46-5)
• EPA Substance Registry System: N2-Methylpyridine-2,6-diaMine(75135-46-5)

Safety Data

• Hazardous Substances Data: 75135-46-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
N2-Methylpyridine-2,6-diamine is used as a building block for the synthesis of various drugs, such as antihistamines, antipsychotics, and antiarrhythmic agents. Its unique chemical structure allows for the development of medications with specific therapeutic properties.
Used in Organic Synthesis:
N2-Methylpyridine-2,6-diamine is employed as a reagent in organic synthesis, facilitating the formation of various chemical compounds and contributing to the advancement of chemical research and development.
Used in Lubricating Oils:
N2-Methylpyridine-2,6-diamine is used as a corrosion inhibitor in lubricating oils, enhancing the performance and longevity of machinery by reducing wear and tear caused by friction and corrosion.

Upstream product

• 141-86-6 2.6-diaminopyridine 
• 74-88-4 methyl iodide 
• 4597-87-9 2-(N-methylamino)pyridine 
• 19798-81-3 2-Amino-6-bromopyridine 
• 74-89-5 methylamine 
• 45644-21-1 6-chloropyridin-2-amine 

Relevant articles and documents

2,6-Diamination of substituted pyridines via heterogeneous Chichibabin reaction

A series of ring substituted pyridines were selected for the sodium amide initiated heterogeneous Chichibabin amination to obtain 2,6-diaminopyridine derivatives which are important synthons for the preparation of PNP pincer ligands. The substrates were treated with an excess of sodium amide in neat mineral oil as solvent under an argon atmosphere. The reaction required temperatures of up to 215°C under vigorous stirring with an overall reaction time of 3-5 h. In the case of methyl, tert-butyl, phenyl, pyridinyl, and hydroxyl substituted pyridines the desired products were obtained in good to excellent yields (63-96%). Thus, the Chichibabin reaction provides an inexpensive and economic alternative to methodologies starting from halopyridines or pyridine N-oxides provided that the substituents are inert under the harsh reaction conditions.

A practical synthesis of substituted 2,6-diaminopyridines via microwave-assisted copper-catalyzed amination of halopyridines

A microwave assisted copper-catalyzed amination protocol is reported utilizing a series of 2,6-dihalo- and 2-amino-6-halo pyridine precursors. Using this procedure, selective substitution of one or two halogens by aryl or alkylamines was achieved within 2-6 h with temperatures between 80 and 225 °C affording 2,6-diaminopyridines in good to excellent isolated yields. The reaction allows easy variation between educts and different N-substitutions. The target compounds are valuable precursors for the synthesis of bis-phosphorylated 2,6-diaminopyridines which are used as PNP pincer ligands in transition metal complexes.

HETEROARYL COMPOUNDS AND USES THEREOF

The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.

QUINAZOLINE DERIVATIVES

The invention concerns quinazoline derivatives of Formula (I) or a pharmaceutically-acceptable salt, solvate or pro-drug thereof, wherein each of X1, p, R1, q, R2, R3, R4, R5, Ring A, r and R6 has any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the treatment of cell proliferative disorders or in the treatment of disease states associated with angiogenesis and/or vascular permeability.