7515-08-4

Basic information

• Product Name: 2-(Dimethoxymethyl)acrylonitrile
• Synonyms: 2-(Dimethoxymethyl)acrylonitrile
• CAS NO: 7515-08-4
• Molecular Formula: C₆H₉NO₂
• Molecular Weight: 0
• Mol File: 7515-08-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(Dimethoxymethyl)acrylonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Dimethoxymethyl)acrylonitrile(7515-08-4)
• EPA Substance Registry System: 2-(Dimethoxymethyl)acrylonitrile(7515-08-4)

Safety Data

• Hazardous Substances Data: 7515-08-4(Hazardous Substances Data)

Upstream product

• 107-31-3 Methyl formate 
• 110-67-8 3-Methoxypropionitrile 
• 124-41-4 sodium methylate 
• 71-43-2 benzene 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 1608-83-9 β,β,β'-trimethoxy-isobutyronitrile 
• 68640-20-0 (E)-3-Methoxy-2-(4-methoxy-3,5-dimethyl-benzyl)-acrylonitrile 
• 68640-19-7 (Z)-3-Methoxy-2-(4-methoxy-3,5-dimethyl-benzyl)-acrylonitrile 
• 68640-22-2 (E)-2-(3,5-Diethyl-4-methoxy-benzyl)-3-methoxy-acrylonitrile 
• 68640-21-1 (Z)-2-(3,5-Diethyl-4-methoxy-benzyl)-3-methoxy-acrylonitrile 
• 7520-73-2 2-Cyan-3-<3,4-dimethoxy-phenyl>-propionaldehyd-dimethylacetal 
• 68640-26-6 3,3-Dimethoxy-2-(3,4,5-trimethyl-benzyl)-propionitrile 
• 68640-27-7 3,3-Dimethoxy-2-(4-methoxy-3,5-dimethyl-benzyl)-propionitrile 
• 68640-25-5 3,3-Dimethoxy-2-(2,3,4-trimethoxy-benzyl)-propionitrile 
• 68640-45-9 2-Dimethoxymethyl-3-phenoxypropionitril 
• 68640-24-4 2-Cyan-1,1,3-triphenylpropan 
• 68640-46-0 3,3-Dimethoxy-2-phenylaminomethyl-propionitrile 
• 68640-16-4 1,2-dimethoxy-4-methyl-5-(2-cyano3-methoxy-2-propenyl)benzene 
• 68640-14-2 (Z)-3-Methoxy-2-(2,3,4-trimethoxy-benzyl)-acrylonitrile 

Relevant articles and documents

Syntheses of Antibacterial 2,4-Diamino-5-benzylpyrimidines. Ormetoprim and Trimethoprim

A general and mild method for the synthesis of 2,4-diamino-5-benzylpyrimidines was achieved by the Friedel-Crafts reaction between 2-(methoxymethylene)-3-methoxypropanenitrile (10) and an activated aromatic substrate followed by treatment with guanidine.The method is illustrated by a synthesis of ormetoprim (2) in 75percent overall yield from 3,4-dimethoxytoluene (12).Efficient syntheses of trimethoprim (1) and 2 were also accomplished via prior base-catalyzed 1,3-prototropic isomerization of cinnamonitriles 19 and 20, respectively, followed by condensation with guanidine. 12 was prepared from 3-bromo-4-methoxytoluene by a Cu(I)-catalyzed displacement of bromine by methoxide and 4,5-dimethoxy-2-methylbenzaldehyde was obtained from 12 in 87percent yield by a pyridine-catalyzed Vilsmeier reaction using DMF-POCl3.