7517-81-9Relevant academic research and scientific papers
De Novo Construction of Substituted Terephthalates via Phosphine Catalyzed Domino Benzannulation Reactions
Wang, Dan,Lin, Junhui,Zhu, Yannan,Huang, You
supporting information, p. 1873 - 1877 (2021/02/16)
The robustness of phosphine catalysis enabling the domino benzannulation reactions of allenoates with enamines is described. A broad array of substituted terephthalates were delivered under simple and practical reaction conditions. Furthermore, the reaction could be carried out on a gram scale with higher yield, and various conversions of the terephthalate products demonstrate the versatility of this transformation. (Figure presented.).
Synthesis of novel benzochromenes using triarylphosphines, alkyl X-phenylpropiolates and 2-hydroxy-1-naphthaldehyde
Gholami, Hamid Reza,Asghari, Sakineh
, p. 206 - 209 (2018/05/26)
The reactions of a series of alkyl X-phenylpropiolates with 2-hydroxy-1-naphthaldehyde and triphenylphosphine led to benzochromenes in moderate yields. When the reactions were performed in the presence of bis(4-methoxyphenyl)phenylphosphine instead of tri
Transition Metal-Free Trans Hydroboration of Alkynoic Acid Derivatives: Experimental and Theoretical Studies
Fritzemeier, Russell,Gates, Ashley,Guo, Xueying,Lin, Zhenyang,Santos, Webster L.
, p. 10436 - 10444 (2018/07/21)
We report a phosphine-catalyzed trans hydroboration of alkynoate esters and amides. The reaction proceeds under mild conditions with exclusive (E)-selectivity to afford (E)-β-boryl acrylates and (E)-β-boryl acrylamides in good to excellent yields. The reaction is tolerant of a variety of functional groups and allows efficient access to novel oxaboroles as well as a pargyline derivative (MAO inhibitor). Theoretical calculations suggest an internal hydride generates a phosphonium allenoxyborane followed by the formation of a key phosphonocyclobutene intermediate that collapses in a stereoselective, rate-limiting step.
Synthesis and rearrangement of dewar benzenes into biaryls: Experimental evidence for conrotatory ring opening
Jankova, Stepanka,Dracinsky, Martin,Cisarova, Ivana,Kotora, Martin
, p. 47 - 51 (2008/09/17)
Rearrangement of aryl-substituted Dewar benzenes into the corresponding biaryls may serve as an alternative pathway for synthesis of sterically hindered biaryls. The kinetic data obtained from thermal rearrangements of Dewar benzenes provide experimental
Synthesis of sterically hindered biaryls by Zr-mediated Co-cyclotrimerization of alkynes
Dufkova, Lenka,Kotora, Martin,Cisarova, Ivana
, p. 2491 - 2499 (2007/10/03)
Treatment of zirconacyclopentadienes with ortho-substituted arylpropynoates in the presence of stoichiometric amounts of CuCl or NiBr 2(PPh3)2 represents a novel approach to the synthesis of biaryls, formed in good yields. The CuCl-mediated reaction proceeded through two reaction mechanisms, also affording Dewar benzenes together with the corresponding biaryls Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005.
Enantioselective synthesis of axially chiral phthalides through cationic [Rh1(H8-binap)]-catalyzed cross alkyne cyclotrimerization
Tanaka, Ken,Nishida, Goushi,Wada, Azusa,Noguchi, Keiichi
, p. 6510 - 6512 (2007/10/03)
(Chemical equation presented). Easy access to axially chiral phthalides that bear one or two oxymethylene functionalities is provided by an enantioselective cross alkyne cyclotrimerization in the presence of the cationic complex [Rh1{(S)-H8-binap}]+. The axial chirality is introduced during the formation of the benzene ring with high enantioselectivity.
Substituted indoles and their use as integrin antagonists
-
, (2008/06/13)
The present invention relates to novel substituted indole compounds that are antagonists of alpha V (αv) integrins, for example αvβ3 and αvβ5 integrins, their pharmaceutically acceptable salts, and pharmaceutical compositions thereof. The compounds may be used in the treatment of pathological conditions mediated by αvβ3 and αvβ5 integrins, including such conditions as tumor growth, metastasis, restenosis, osteoporosis, inflammation, macular degeneration, diabetic retinopathy, and rheumatoid arthritis. The compounds have the general formula: where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, D, X, W, a, m, n, i, j, k and v are defined herein.
Synthesis of 2-amino-6-phenyl-4H-pyran-4-ones
Morris,Wishka
, p. 43 - 46 (2007/10/02)
The treatment of a series of phenylacetylenic β-keto amides with methanesulfonic acid produces a high yielding intramolecular cyclization to the corresponding 2-amino-6-phenyl-4H-pyran-4-ones.
