75220-81-4Relevant academic research and scientific papers
Synthesis and biological screening of some new 1,5-benzodiazepine derivatives as promising antibacterial and antitubercular agents
Monga, Vikramdeep,Nayak, Surendra Kumar,Singh, Gurpreet
, p. 143 - 149 (2020/07/21)
In this study, various substituted 1,5-benzodiazepines were synthesized by condensing different substituted chalcones with o-phenylenediamine in methanol using piperidine as a base under refluxing conditions and were obtained in good yield after purificat
Construction of the 1,5-Benzodiazepine Skeleton from o-Phenylendiamine and Propargylic Alcohols via a Domino Gold-Catalyzed Hydroamination/Cyclization Process
Cacchi, Sandro,Fabrizi, Giancarlo,Goggiamani, Antonella,Iazzetti, Antonia
supporting information, p. 3511 - 3513 (2016/08/16)
The gold-catalyzed reaction of o-phenylendiamine with propargylic alcohols affords 1,5-benzodiazepines bearing different substituents on the 2 and 4 positions. The method allows even for the selective preparation of 4-substituted 1,5-benzodiazepine derivatives.
Protic acidic ionic liquids promoted formation of 1,5-benzodiazepines: Remarkable effects of cations and anions on their performances
Du, Yuying,Tian, Fuli
, p. 486 - 489 (2007/10/03)
A series of protic acidic ionic liquids have been used as solvents and catalysts for the synthesis of 1,5-benzodiazepines. Success of the condensation appears to lie in the choice of cation-anion combinations and the ionic liquid [HBIm]CF3SOsu
Solvent-free synthesis of 1,5-benzothiazepines and benzodiazepines on inorganic supports
Kodomari, Mitsuo,Noguchi, Tomohiro,Aoyama, Tadashi
, p. 1783 - 1790 (2007/10/03)
1,5-Benzothiazepines and 1,5-benzodiazepines have been synthesized in solvent-free conditions from chalcones and o-aminothiophenol or o-phenylenediamine in the presence of inorganic support. Silica gel was found to be an effective support for the synthesi
On the mechanism and stereochemistry of the formation of β-lactam derivatives of 2,4-disubstituted-2,3-dihydro-benzo[1,4]diazepines
Wang,Zhou,Xu,Jin,Li,Chan
, p. 1031 - 1034 (2007/10/03)
2-Chloro-4-phenyl-2a-(4′-methoxyphenyl)-3,5-dihydroazatetracylic [1,2-d]benzo[1,4]diazepin-1-one (IIIa) and 2-chloro-4-phenyl-2a-(4′-methoxyphenyl)-3,5-dihydroazatetracyclic [1,2-d]benzo[1,4]diazepin-1-one(IIIb) were synthesized. 1-B
NEW ASPECTS OF THE CHEMISTRY OF 2,3-DIHYDRO-1H-1,5-BENZODIAZEPINE
Orlov, V. D.,Kolos, N. N.,Yaremenko, F. G.,Lavrushin, V. F.
, p. 547 - 550 (2007/10/02)
Under basic catalysis conditions the reaction of 4- and 4'-substituted chalcones with o-phenylenediamine leads to 2,3-dihydro-2,4-diaryl-1H-1,5-benzodiazepines; β-amino adducts, the ability of which to undergo intramolecular condensation increases as the
