752233-11-7

Upstream product

• 39103-38-3 (E)-2-styrylchromone 
• 39103-35-0 3-hydroxy-1-(2-hydroxyphenyl)-5-phenylpenta-2,4-dien-1-one 
• 205308-02-7 (E)-1-(2-hydroxyphenyl)-5-phenylpent-4-ene-1,3-dione 
• 118-93-4 o-hydroxyacetophenone 
• 16636-62-7 1-(2'-hydroxyphenyl)butane-1,3-dione 
• 69932-31-6 3-bromo-2-methyl-4H-chromen-4-one 
• 100-52-7 benzaldehyde 
• 7250-94-4 o-acetoxyacetophenone 

Downstream Products

• 882303-11-9 3-phenyl-2-(4-methoxyphenyl)xanthone 
• 882303-12-0 2-(3,4-dimethoxyphenyl)-3-phenyl-9H-xanthen-9-one 

Relevant academic research and scientific papers

(E)-3-Halo-2-styryl-4H-chromen-4-ones: Synthesis and transformation to novel pyrazoles

New methods for the synthesis of (E)-3-halo-2-styryl-4H-chromen-4-ones were established. The reaction of these compounds with hydrazine hydrate afforded new and unexpected 3(5)-aryl-5(3)-[2-(2-hydroxyphenyl)-2-hydrazonoethyl]-1H- pyrazoles, which upon aci

Stereoselective bromination of 2-vinyl chromones using NBS

A simple one-step synthetic methodology for stereoselective synthesis of E- and Z-3-bromo-2-vinyl chromones in quantitative yield in polar solvents under ambient conditions without the use of catalysts is reported. Copyright Taylor & Francis Group, LLC.

Synthesis and docking studies on styryl chromones exhibiting cytotoxicity in human breast cancer cell line

The search for small molecules that preferentially target the functionally important surfaces of estrogen receptor and disrupt the transcriptional activity in the cell has emerged as a promising area towards rationale based drug design. Herein, we report substituted styryl chromones as a new class of compounds that exhibit selectivity for ERβ binding at the second binding site of HT and antiproliferative activity in human breast cancer cell line.

Efficient syntheses of new polyhydroxylated 2,3-diaryl-9H-xanthen-9-ones

A large number of hydroxylated 2,3-diaryl-9/i-xanthen-9ones have been synthesised by two different approaches, starting either from 3-brom.o-2-m.elhyl-4H-ch:rom.en-4-one or from. (E)-3-brom.o-2-styryl-4H-chrom. en-4-ones. The former method involves Heck r

A novel and efficient route for the synthesis of hydroxylated 2,3-diarylxanthones

A novel, efficient and general route for the synthesis of hydroxylated 2,3-diarylxanthones is described. 3-Bromo-2-styryl-chromone, the key intermediate of this synthesis, is obtained by a Baker-Venkataraman rearrangement of the appropriate 2′-cinnamoylox

New synthesis of 2,3-diarylxanthones

A new synthesis for 2,3-diarylxanthones is described. This was accomplished by aldol condensation of 3-bromo-2-methylchromone with benzaldehydes leading to the formation of 3-bromo-2-styrylchromones, followed by Heck reaction with styrenes. Georg Thieme V

Bromination and azidation reactions of 2-styrylchromones. New syntheses of 4(5)-aryl-5(4)-(2-chromonyl)-1,2,3-triazoles

The bromination of 2-styrylchromones, bearing electron neutral substituents, with two molar equivalents of piridinium tribromide gave 2-(2-aryl-1,2-dibromoethyl)chromones and 3-bromo-2-(2-aryl-1,2-dibromoethyl) chromones. The presence of electron-donating substituents on their B ring led to a mixture of compounds due to the higher reactivity of their C(2)=C(3) and Cα=Cβ double bonds, whereas the strongly electron-withdrawing group hindered the bromination. The dehydrobromination of 2-(2-aryl-1,2-dibromoethyl)chromones with triethylamine gave a diastereomeric mixture of (E)- and (Z)-2-(α-bromostyryl)chromones. Some novel 4(5)-aryl-5(4)-(2-chromonyl)-1,2,3-triazoles have been obtained from the reactions of 2-(2-aryl-1,2-dibromoethyl)chromones, 2-(α-bromostyryl) chromones, and 2-styrylchromones with sodium azide. The reactions of 2-styrylchromones with sodium azide are more efficient, general, and constitute a one-pot synthetic method of 4(5)-aryl-5(4)-(2-chromonyl)-1,2,3-triazoles allowing the preparation of 1,2,3-triazoles bearing either electron-donating or electron-withdrawing substituents in their aryl ring. The structure of all new compounds was established by extensive NMR spectroscopic studies. Springer-Verlag 2003.

New syntheses of 4(5)-aryl-5(4)-(2-chromonyl)-1,2,3-triazoles from 2- styrylchromones and sodium azide

The reactions of 2-α-bromostyrylchromones or 2-styrylchromones with sodium azide afforded 4(5)-aryl-5(4)-(2-chromonyl)-1,2,3-triazoles. In the case of 2-α-bromostyrylchromones, the unexpected 1-aryl-5-(2-chromonyl- methyl)tetrazoles have been obtained as minor products and the mechanism of its formation is discussed. The bromination/dehydrobromination reactions of 2-styrylchromones were also studied.