7526-25-2

Upstream product

• 18351-42-3 dimethyl phenylphosphonite 
• 74-88-4 methyl iodide 
• 67-56-1 methanol 
• 108-95-2 phenol 
• 690-64-2 isopropyl methyl methylphosphonate 

Downstream Products

• 199855-72-6 (Methoxy-phenoxy-phosphorylmethyl)-phosphonic acid dimethyl ester 
• 199855-77-1 [Dichloro-(methoxy-phenoxy-phosphoryl)-methyl]-phosphonic acid dimethyl ester 

Relevant academic research and scientific papers

METHOD FOR PRODUCING ORGANOPHOSPHORUS COMPOUND

PROBLEM TO BE SOLVED: To provide a method for producing an organophosphorus compound which has excellent energy efficiency without containing a halogenated alkyl or a by-product derived from a halogenated alkyl. SOLUTION: There is provided a method for producing an organophosphorus compound by reacting a trivalent organophosphorus compound represented by the following general formula (1) in the presence of a super strong acid and/or at least one acid catalyst containing a solid superstrong acid catalyst to generate a pentavalent organophosphorus compound represented by the following general formula. (where Z1 represents OR2 or R2; Z2 represents OR3 or R3; R1, R2 and R3 represent an alkyl group, an alkenyl group or the like; when R2 and R3 are an alkyl group or the like, R2 and R3 may be bonded to each other to form a cyclic structure; and R1 may be a hydrogen atom.) SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT

Water determines the products: An unexpected Br?nsted acid-catalyzed PO-R cleavage of P(iii) esters selectively producing P(O)-H and P(O)-R compounds

Water is found able to determine the selectivity of Br?nsted acid-catalyzed C-O cleavage reactions of trialkyl phosphites: with water, the reaction quickly takes place at room temperature to afford quantitative yields of H-phosphonates; without water, the reaction selectively affords alkylphosphonates in high yields, providing a novel halide-free alternative to the famous Michaelis-Arbuzov reaction. This method is general as it can be readily extended to phosphonites and phosphinites and a large scale reaction with much lower loading of the catalyst, enabling a simple, efficient, and practical preparation of the corresponding organophosphorus compounds. Experimental findings in control reactions and substrate extension as well as preliminary theoretical calculation of the possible transition states all suggest that the monomolecular mechanism is preferred.

Copper-catalyzed synthesis of mixed alkyl aryl phosphonates

Copper-catalysis allows the direct oxygen-arylation of dialkyl phosphonates with diaryliodonium salts. This novel methodology proceeds with a wide range of phosphonates and phosphoramidates under mild conditions and gives straightforward access to valuable mixed alkyl aryl phosphonates in very good yields and near perfect selectivity.

Strategies for the selective synthesis of monosubstituted (Dichloromethylene)bisphosphonate esters

Strategies for the selective synthesis of monosubstituted (dichloromethylene)bisphosphonate esters (Cl2C[P(O)(OR)(O-Na+)][P(O)(O- Na+)2], where R = Pr, Pr(i), Hex, Ph) starting from monopho