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Usage

Uses

Used in Pharmaceutical Industry:
Ethanone, 1-(2-benzofuranyl)-2,2,2-trifluoro(9CI) is utilized as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows it to be incorporated into drug molecules, potentially enhancing their efficacy and selectivity. Ethanone, 1-(2-benzofuranyl)-2,2,2-trifluoro(9CI)'s ability to modulate biological targets and pathways is being explored for the development of new therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, Ethanone, 1-(2-benzofuranyl)-2,2,2-trifluoro(9CI) serves as a building block for the creation of novel agrochemicals. Its incorporation into these products can lead to improved pest control and crop protection, as well as reduced environmental impact. Ethanone, 1-(2-benzofuranyl)-2,2,2-trifluoro(9CI)'s potential to target specific pests and diseases while minimizing harm to beneficial organisms is a key area of research.
Further research is necessary to fully elucidate the potential uses and effects of Ethanone, 1-(2-benzofuranyl)-2,2,2-trifluoro(9CI) in these and other industries. As our understanding of its properties and interactions with biological systems grows, it is likely that new applications and opportunities will emerge, further expanding the utility of this intriguing chemical compound.

Upstream product

• 271-89-6 1-benzofurane 
• 1547-87-1 N,N-dimethyl-2,2,2-trifluoroacetamide 
• 407-25-0 trifluoroacetic anhydride 
• 98437-24-2 benzofuran-2-boronic acid 
• 181820-18-8 S-(tert-butyl)trifluorothioacetate 
• 496-41-3 Benzofuran-2-carboxylic acid 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 1187023-87-5 1-(benzofuran-2-yl)-2,2,2-trifluoroethan-1-ol 
• 4265-16-1 2-formylbenzo[b]furan 
• 55038-01-2 benzofuran-2-yl-methanol 
• 3199-61-9 ethyl coumarilate 
• 90-02-8 salicylaldehyde 
• 383-63-1 ethyl trifluoroacetate, 

Relevant academic research and scientific papers

Trifluoromethylation of Benzoic Acids: An Access to Aryl Trifluoromethyl Ketones

The trifluoromethylation of benzoic acids with TMSCF3 was achieved through nucleophilic substitution with the use of anhydrides as an in situ activating reagent. Under the reaction conditions, a wide range of carboxylic acids including the bioactive ones worked well, thus providing a facile and efficient method for preparing aryl trifluoromethyl ketones from the readily available starting materials.

Palladium-catalyzed fluoroacylation of (Hetero)arylboronic acid with fluorothioacetates at ambient temperature

A palladium-catalyzed fluoroacylation of (hetero)aryl boronic acid with the fluorothioacetates is described at ambient temperature. A variety of aryl, and heteroaryl boronic acids are compatible in the reaction, affording the corresponding fluoroalkyl ketones in moderate to good yields. Further late-stage di-, and trifluoroacylation of drug molecule clofibrate and estrone demonstrated the synthetic practicability of this protocol.2009 Elsevier Ltd. All rights reserved.

Palladium-Catalyzed Trimethylenemethane Cycloaddition of Olefins Activated by the δ-Electron-Withdrawing Trifluoromethyl Group

α-Trifluoromethyl-styrenes, trifluoromethyl-enynes, and dienes undergo palladium-catalyzed trimethylenemethane cycloadditions under mild reaction conditions. The trifluoromethyl group serves as a unique δ-electron-withdrawing group for the activation of the olefin toward the cycloaddition. This method allows for the formation of exomethylene cyclopentanes bearing a quaternary center substituted by the trifluoromethyl group, compounds of interest for the pharmaceutical, agrochemical, and materials industries. In the diene series, the cycloaddition operates in a [3 + 4] and/or [3 + 2] manner to give rise to seven- and/or five-membered rings. This transformation greatly improves the scope of the TMM cycloaddition technology and provides invaluable insights into the reaction mechanism.

Synthesis of Perfluoroalkyl-Substituted Vinylcyclopropanes by Way of Enhanced Neighboring Group Participation

A simple, high yielding, two-step, one-pot protocol for the preparation of trifluoromethyl-substituted vinylcyclopropanes from α-CF3 homoallyl alcohols is disclosed. Destabilization of the cationic intermediate by the electron-withdrawing CF3 group greatly enhances neighboring group participation of the alkene, allowing ring closure to predominate. The reaction can be extended to the difluoromethyl and pentafluoroethyl group, enabling the preparation of a diverse array of fluoroalkyl-substituted vinylcyclopropanes. A diverse array of fluoroalkyl-substituted vinylcyclopropanes are prepared in a simple, high-yielding, two-step, one-pot protocol by means of cationic ring-closure.

A facile synthesis of aryl trifluoromethyl ketones

The reaction of arylcopper reagents with α,α,α-trifluoroacetic anhydride gives the corresponding aryl trifluoromethyl ketones in good yields.

A Convenient Preparation of Aryltrifluoromethylketones

The reaction of aryllithium reagents prepared by halogen metal exchange or direct metallation with α,α,α-trifluoro-N,N-dimethylacetamide give the corresponding aryltrifluoromethylketones in good yield.