752977-73-4

Upstream product

• 444896-34-8 4-(1-cyclohexyl-2-diethylamino-ethyl)-piperazine-1-carboxylic acid tert-butyl ester 
• 444893-43-0 4-(1-cyclohexyl-2-oxo-ethyl)-piperazine-1-carboxylic acid tert-butyl ester 
• 444893-42-9 4-(1-cyclohexyl-2-hydroxy-ethyl)-piperazine-1-carboxylic acid tert-butyl ester 
• 444893-16-7 4-(cyclohexyl-methoxycarbonyl-methyl)-piperazine-1-carboxylic acid tert-butyl ester 
• 5292-21-7 Cyclohexylacetic acid 
• 90085-61-3 2-bromocyclohexylacetylchloride 
• 58851-63-1 Brom-cyclohexylessigsaeure-methylester 
• 23860-35-7 cyclohexylacetic acid chloride 

Downstream Products

• 900535-61-7 1-({1-(4-chloro-benzyl)-2-[4-(1-cyclohexyl-2-diethylamino-ethyl)-piperazin-1-yl]-2-oxo-ethylcarbamoyl}-methyl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester 
• 900535-57-1 3-{1-(4-chloro-benzyl)-2-[4-(1-cyclohexyl-2-diethylamino-ethyl)-piperazin-1-yl]-2-oxo-ethylcarbamoyl}-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Privileged structure based ligands for melanocortin-4 receptors-Aliphatic piperazine derivatives

Aliphatic carbocyclic replacement of the benzyl group of compound 1 yielded compounds with high affinity for the melanocortin-4 receptor (MC4R). Compounds with a cyclohexyl group showed a consistent high affinity, while different polar groups with less basicity were good replacements for the original diethyl amines. Substitution of the polar group found in these privileged structures with an aliphatic moiety produced compounds with high affinity for MC4R.

ACYLATED PIPERAZINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR AGONISTS

Certain novel N-acylated piperazine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention