753016-45-4

Upstream product

• 55776-46-0 (3'E)-3-(5'-benzyloxy-3'-methylpent-3'-enyl)-2,2-dimethyloxirane 
• 32989-52-9 (E)-4-methyl-6-(phenylmethoxy)-4-hexenal 
• 753016-43-2 (E)-(S)-6-Benzyloxy-2,4-dimethyl-hex-4-enoic acid methyl ester 
• 157733-27-2 (E)-(3'-bromo-but-2'-enyloxymethyl)-benzene 
• 680201-71-2 1-hydroxy-2-(hydroxymethyl)-3-pentanone 
• 680201-67-6 (S)-1-(tert-butyldiphenylsiloxy)-2-(4-methoxybenzyloxymethyl)-3-pentanone 
• 753016-63-6 (E)-(S)-6-Benzyloxy-2,4-dimethyl-hex-4-en-1-ol 
• 753016-41-0 (E)-(S)-6-Benzyloxy-2,4-dimethyl-hex-4-enal 
• 865378-37-6 (E)-6-Benzyloxy-4-methyl-hex-4-enoic acid 
• 100-39-0 benzyl bromide 
• 52188-73-5 geranyl benzyl ether 
• 106-24-1 Geraniol 
• 865378-39-8 (S)-4-Benzyl-3-((E)-(S)-6-benzyloxy-2,4-dimethyl-hex-4-enoyl)-oxazolidin-2-one 
• 865378-38-7 (S)-4-Benzyl-3-((E)-6-benzyloxy-4-methyl-hex-4-enoyl)-oxazolidin-2-one 

Downstream Products

• 753016-64-7 (E)-(2R,3S,4S,5R,6S)-10-Benzyloxy-2-(4-methoxy-benzyloxymethyl)-4,6,8-trimethyl-dec-8-ene-1,3,5-triol 
• 753016-47-6 (4R,5S)-4-[(E)-(1R,2R,3S)-7-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-1,3,5-trimethyl-hept-5-enyl]-2,2-dimethyl-[1,3]dioxane-5-carbaldehyde 
• 753016-65-8 (E)-(2S,3R,4S)-8-Benzyloxy-2-[(4S,5S)-5-(4-methoxy-benzyloxymethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-4,6-dimethyl-oct-6-en-3-ol 
• 753016-66-9 {(4S,5S)-4-[(E)-(1R,2R,3S)-7-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-1,3,5-trimethyl-hept-5-enyl]-2,2-dimethyl-[1,3]dioxan-5-yl}-methanol 
• 753016-67-0 (E)-3-{(4S,5S)-4-[(E)-(1R,2R,3S)-7-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-1,3,5-trimethyl-hept-5-enyl]-2,2-dimethyl-[1,3]dioxan-5-yl}-2-methyl-prop-2-en-1-ol 
• 92090-94-3 (-)-kazusamycin A 
• 753016-68-1 (4S,5S)-4-[(E)-(1R,2R,3S)-7-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-1,3,5-trimethyl-hept-5-enyl]-2,2-dimethyl-5-((E)-2-methyl-3-triisopropylsilanyloxy-propenyl)-[1,3]dioxane 
• 860160-10-7 (E)-3-{(4S,5S)-4-[(E)-(1R,2R,3S)-7-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-1,3,5-trimethyl-hept-5-enyl]-2,2-dimethyl-[1,3]dioxan-5-yl}-2-methyl-acrylic acid ethyl ester 
• 753016-46-5 ((E)-(1R,2S)-6-Benzyloxy-1-{(R)-1-[(4S,5S)-5-(4-methoxy-benzyloxymethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-ethyl}-2,4-dimethyl-hex-4-enyloxy)-tert-butyl-dimethyl-silane 

Relevant academic research and scientific papers

A practical synthesis of (-)-kazusamycin A (revised)

We describe herein a stereo-controlled and practical synthesis of three key building blocks, namely Segment AB′, Segment D, and Segment E′ needed for the total synthesis of (-)-kazusamycin A.

First total synthesis of the antitumor compound (-)-kazusamycin A and absolute structure determination

(Equation Presented) The first total synthesis of kazusamycin A, a potent antitumor compound from an actinomycete, has been achieved, and its absolute structure was determined. Paterson's stereoselective aldol reaction was successfully applied to construct the contiguous chiral centers by using an originally designed optically active 2-acyl-1,3-propanediol derivative.