32989-52-9Relevant academic research and scientific papers
Osmium-mediated oxidative cyclizations: A study into the range of initiators that facilitate cyclization
Donohoe, Timothy J.,Wheelhouse, Katherine M. P.,Lindsay-Scott, Peter J.,Churchill, Gwydion H.,Connolly, Matthew J.,Butterworth, Sam,Glossop, Paul A.
scheme or table, p. 1237 - 1247 (2010/04/23)
A general route to prepare substituted, saturated five-membered heterocycles has been developed. The application of a wide range of starting materials to the osmium-catalyzed oxidative cyclization reaction is described. Diols, hydroxy-amides, hydroxy-sulf
A practical synthesis of (-)-kazusamycin A (revised)
Zhou, Shengfeng,Chen, Huaxiang,Liao, Wensheng,Chen, Shu-Hui,Li, Ge,Ando, Ryoichi,Kuwajima, Isao
, p. 6341 - 6344 (2007/10/03)
We describe herein a stereo-controlled and practical synthesis of three key building blocks, namely Segment AB′, Segment D, and Segment E′ needed for the total synthesis of (-)-kazusamycin A.
Chemoenzymatic synthesis of (E)-3,7-dimethyl-2-octene-1,8-diol isolated from the hairpencils of male Danaus chrysippus (African Monarch)
Takabe, Kunihiko,Mase, Nobuyuki,Hashimoto, Hiroya,Tsuchiya, Atsushi,Ohbayashi, Takashi,Yoda, Hidemi
, p. 1967 - 1969 (2007/10/03)
The synthesis of (E)-3,7-dimethyl-2-octene-1,8-diol (1), which was isolated from the hairpencils of male Danaus chrysippus (African Monarch), was investigated. The key step of the sequence involves asymmetric desymmetrization of the 1,3-propanediol 7 with
Total synthesis of (+)-curacin A, a marine cytotoxic agent
Hoemann, Michael Z.,Agrios, Konstantinos A.,Aube, Jeffrey
, p. 11087 - 11098 (2007/10/03)
The total synthesis of curacin A, a cytotoxic agent that interacts with the colchicine binding site on tubulin, is described. The convergent synthesis utilizes natural product and chiral pool starting materials (geraniol, serine) and asymmetric synthesis
Z-selective formation of trisubstituted α,β-unsaturated nitrile by the Horner-Emmons reaction
Takayanagi, Hisao
, p. 1581 - 1584 (2007/10/02)
Conditions which allow the Horner-Emmons reaction of phosphononitrile to proceed Z-selectively were clarified. The generality and usefulness of the procedure were demonstrated by an application to a stereoselective synthesis of plaunotol (9).
Highly Efficient Construction of the 7-Azabicyclonon-2-ene System. An Application to the Synthesis of the AEF Ring System of Aconitine-type Diterpene Alkaloids
Shishido, Kozo,Hiroya, Kou,Fukumoto, Keiichiro,Kametani, Tetsuji
, p. 867 - 893 (2007/10/02)
The Mannich-type cyclisation of the cyclohexenylamine hydrochlorides (3 and 6) with 37percent aqueous formaldehyde in acetic acid at 150 deg C in a sealed tube afforded the bicyclic amines (9 and 10) in excellent yields.Under the same conditions, the amin
Highly Stereoselective Total Synthesis of Plaunotol
Sato, Kikumasa,Miyamoto, Osamu,Inoue, Seiichi,Iwase, Norimichi,Honda, Kiyoshi
, p. 1433 - 1436 (2007/10/02)
Highly stereoselective total synthesis of plaunotol has been achieved by the application of the (Z)-stereoselective direct Wittig olefination to α-alkoxy ketones having geranylacetone skeleton.
The Synthesis of Cembranolide Precursors via Addition of Allylstannanes to Conjugated Aldehydes
Marshall, James A.,DeHoff, Bradley S.
, p. 863 - 872 (2007/10/02)
The Lewis acid promoted addition of functionalized allylstannanes A9, C10, and C11 to a variety of conjugated aldehydes was examined as a possible route to acyclic precursors of macrocyclic diterpenoids.Additions to crotonaldehyde proceeded as expected, g
Total Syntheses of Fungal Metabolites and Functionalized Furanones
Chen, Kau-Ming,Semple, J. Edward,Joullie, Madeleine M.
, p. 3997 - 4005 (2007/10/02)
Simple, efficient syntheses of the fungal metabolites colletochlorin D and (+/-)-ascofuranone and one of its stereoisomers are described.Our investigations of functionalized furanones also enabled us to develop a nine-step (22percent overall yield) synthe
