753025-13-7

Upstream product

• 98-68-0 4-methoxy-phenyl-sulphonyl chloride 
• 238749-51-4 ethyl 1-methyl-1,4-dihydropyrrolo[2,3-d]imidazole-5-carboxylate 
• 753025-10-4 ethyl α-azido-β-(1-methylimidazole-5-yl)acrylate 
• 143122-18-3 5-hydroxymethyl-2-mercapto-1-methyl-1H-imidazole 
• 38993-84-9 (1-methyl-1H-imidazol-5-yl)methanol 
• 39021-62-0 1-methylimidazole-5-carbaldehyde 

Relevant academic research and scientific papers

Chemo- and regioselectivity in the reactions between highly electrophilic fluorine containing dicarbonyl compounds and amines. Improved synthesis of the corresponding imines/enamines

Chemo- and regioselectivity in the reactions between highly electrophilic fluorine containing dicarbonyl compounds (ethyl 4,4,4-trifluoroacetoacetate, 3,3,3-trifluoropyruvate and 1,1,1,5,5,5-hexafluoropentane-2,4-dione) and various benzylamines were systematically studied. The results obtained lead to the development of a generalized and practical method for large-scale synthesis of the corresponding imines/enamines, useful starting materials for preparation fluorinated amines and amino acid.

Synthesis and anti-inflammatory activity of new 1-methyl-4-(4-X-benzenesulfonyl)pyrrolo[2,3-d] imidazole-5-carboxylates

A series of 1-methyl-4-(4-X-arylsulfonyl)pyrrolo[2,3-d]imidazole-5-carboxylates were synthesized and tested as anti-inflammatory agents. Indomethacin was used as reference drug. Two of the synthesized compounds 7a and 7b had an effect equal to 0.1 of indomethacin. Our result showed that the electron-withdrawing substituents in the para position of the benzensulfonyl moiety increase activity.