75303-08-1

Upstream product

• 14003-34-0 3-methyl-2-oxo-1,2-dihydroquinoxaline 
• 100-52-7 benzaldehyde 
• 95-54-5 1,2-diamino-benzene 
• 1914-59-6 (E)-2-oxo-4-phenyl-3-butenoic acid 

Downstream Products

• 101874-99-1 3-(α,β-bis-thiocyanato-phenethyl)-1H-quinoxalin-2-one 
• 106203-57-0 3-(2'-phenylethyl)-2(1H)-quinoxalinone 
• 101423-50-1 3-(α,β-dichloro-phenethyl)-1H-quinoxalin-2-one 
• 83451-41-6 3-(α,β-dibromo-phenethyl)-1H-quinoxalin-2-one 
• 112349-14-1 1-[2-(3-oxo-3,4-dihydro-quinoxalin-2-yl)-1-phenyl-vinyl]-pyridinium; bromide 
• 63186-24-3 3-phenyl-1,2-dihydro-pyridazino[3,4-b]quinoxaline 
• 88051-11-0 3-bromo-2-phenylfuro<2,3-b>quinoxaline 
• 22298-77-7 3-phenacylidene-3,4-dihydro-1H-quinoxalin-2-one 
• 132467-02-8 3-(β-chloro-styryl)-1H-quinoxalin-2-one 
• 101291-14-9 3-phenylacetylquinoxaline-2(1H)-one 
• 37052-98-5 2-phenylfuro<2,3-b>quinoxaline 

Relevant academic research and scientific papers

Experimental and theoretical studies for mild steel corrosion inhibition in 1.0 M HCl by three new quinoxalinone derivatives

Three quinoxalinone derivatives, namely (E)-3-styrylquinoxalin-2(1H)-one (SQ), (E)-3-(4-methoxystyryl)quinoxalin-2(1H)-one (MOSQ) and (E)-3-(4-methoxystyryl)-7-methylquinoxalin-2(1H)-one (MOSMQ) were synthesized and characterized. Thus, their inhibition e

Malononitrile-activated synthesis and anti-cholinesterase activity of styrylquinoxalin-2(1: H)-ones

Herein, we report a base-free malononitrile activated condensation of 3-methylquinoxaline-2(1H)-one (3MQ) 1 with aryl aldehydes 3a-3ad for synthesis of styrylquinoxalin-2(1H)-ones (SQs) 4a-4ad with excellent yields. In this reaction, malononitrile activates the aldehyde via Knoevenagel condensation towards reaction with 3MQ 1 and gets liberated during the course of reaction to yield the desired SQs 4a-4ad. The SQs were evaluated for in vitro cholinesterase inhibition and 4n was found to display a mixed type of inhibition of AChE, which was supported by molecular modelling studies. This study has led to the discovery of a new chemotype for cholinesterase inhibition which might be useful in finding a remedy for Alzheimer's disease.

Styrylbenzodiazinones 1. Synthese, structure et proprietes photophysiques

Several 3-styryl derivatives of 1,4-benzodiazine-2-one and of 1-methyl-1,4-benzodiazine-2-one were prepared.A structural study of these compounds by 1H and 13C NMR and by molecular modelling was carried out.The rotational isomerism around the bond connecting the imine and vinyl groups in these E styrylbenzodiazinones is discussed.The s-cis rotamer is shown to be the predominant isomer.The photophysical properties of these fluorescent dyes are reported.

Reaction of Quinaxoline Derivatives with Nucleophilic Reagents

2-Chloro-3-methylquinoxaline reacts with aromatic amines in basic medium forming 2-arylamino-3-methylquinoxalines, also it reacts with mercaptoacetic acid.The 3-methyl-2(1H)-quinoxalinone condenses with aromatic aldehydes forming the corresponding 3-(subs