75335-47-6

Upstream product

• 1080-12-2 Dehydrozingerone 
• 100-44-7 benzyl chloride 
• 1080-12-2 (E)-4-(4-hydroxy-3-methoxyphenyl)but-3-ene-2-one 
• 100-39-0 benzyl bromide 
• 2426-87-1 3-methoxy-4-(phenylmethoxy)benzaldehyde 
• 4202-14-6 dimethyl (2-oxopropyl)phosphonate 
• 67-64-1 acetone 
• 77795-22-3 4-benzyloxy-3-methoxycinnamic acid 

Downstream Products

• 1108610-70-3 (E)-4-[4-(benzyloxy)-3-methoxyphenyl]-1-iodobut-3-en-2-one 
• 1350624-39-3 (E)-4-(4-(benzyloxy)-3-methoxyphenyl)-2-oxobut-3-en-1-yl acetate 
• 1597410-36-0 (E)-S-methyl 4-(4-(benzyloxy)-3-methoxyphenyl)-2-oxobut-3-enethioate 
• 1338577-31-3 3-O-[(E)-4-(3-methoxy-4-benzyloxy phenyl)-2-oxobut-3-en-1-yl]kaempferol 
• 1666-13-3 diphenyl diselenide 
• 39886-78-7 4-[4-(benzyloxy)-3-methoxyphenyl]butan-2-one 
• 75335-20-5 3-(4-Benzyloxy-3-methoxyphenyl)-4,4-dimethoxy-2-butanon 
• 943330-36-7 (E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hept-1-ene-3,5-dione 
• 105245-82-7 (E)-1,7-Bis-(4-benzyloxy-3-methoxy-phenyl)-hept-1-ene-3,5-dione 

Relevant academic research and scientific papers

Aminium cation-radical catalysed selective hydration of (E)-aryl enynes

The hydration of carbon-carbon triple bonds is an important and atom economic synthetic transformation. Herein, we report a mild and selective method for the catalytic Markovnikov hydration of (E)-aryl enynes to the corresponding enones, mediated through the bench-stable aminium salt, tris(4-bromophenyl)ammoniumyl hexachloroantimonate (TBPA). The chemoselective and diastereoselective method proceeds under neutral metal-free conditions, delivering excellent product yields from terminal and internal alkyne units. The synthesis of biologically important (E)-3-styrylisocoumarins, including a formal synthesis of the natural product achlisocoumarin III, demonstrates the utility of this novel transformation.

PPh3·HBr-DMSO mediated expedient synthesis of γ-substituted β,γ-unsaturated α-ketomethylthioesters and α-bromo enals: Application to the synthesis of 2-methylsulfanyl-3(2 H)-furanones

An efficient chemoselective general procedure for the synthesis of γ-substituted β,γ-unsaturated α-ketomethylthioesters from α,β-unsaturated ketones has been achieved through an unprecedented PPh3·HBr-DMSO mediated oxidative bromination and Kornblum oxidation sequence. The newly developed reagent system serves admirably for the synthesis of α-bromoenals from enals. Furthermore, AuCl 3-catalyzed efficient access to 3(2H)-furanones from the above intermediates under extremely mild conditions are described. Copyright

Synthesis and biological activity of novel tiliroside derivants

A series of new tiliroside derivatives were synthesized and characterized by analytical 1H NMR, 13C NMR and mass spectrometry. All of the compounds were evaluated for anti-diabetic properties in vitro using HepG2 cells. Compounds 3c, 3d, and 3i-l caused significant enhancements in glucose consumption by insulin-resistant HepG2 cells compared with control cells and cells that were exposed to metformin (an anti-diabetic drug). Moreover, compound 3l significantly activated adenosine 5′-monophosphate-activated protein kinase activity and reduced acetyl-CoA carboxylase activity. Thus, the tiliroside derivative 3l offers potential to be developed as a new approach for treating type II diabetes.

An efficient method for the selective iodination of ?±,?2- unsaturated ketones

An efficient approach to ?±,?2-unsaturated ?±'-iodo ketones directly from ?±,?2-unsaturated ketones by selective iodination at the ?±'-position, without effect on the double bond and the activated benzene ring, in the presence of copper (II) oxide/iodine is described. The present method has the advantages of high yields, short reaction times, inexpensive reagents, mild reaction conditions, ease of manipulation, and the formation of cleaner products. ? Georg Thieme Verlag Stuttgart ?· New York.

Triphenylphosphine oxide complex process

A process for reducing the level of tri-substituted phosphine, arsine and/or stibine oxide from a mixture comprising a desired product and at least one such oxide is provided, comprising the addition of a metal salt to the mixture to form a complex with the oxide, and removing the complex from the mixture. This process has particular utility for removing triphenylphosphine oxide from a mixture-a task that was previously hard to perform.

Process for reducing the level of trisubstituted phosphine, arsine and/or stibine oxide in a mixture

A process for reducing the level of tri-substituted phosphine, arsine and/or stibine oxide from a mixture comprising a desired product and at least one such oxide is provided, comprising the addition of a metal salt to the mixture to form a complex with the oxide, and removing the complex from the mixture. This process has particular utility for removing triphenylphosphine oxide from a mixture - a task that was previously hard to perform.

Synthesis of Dihydrocurcumin

Dihydrocurcumin is synthesised by C-acylation of 4-O-benzylvanillylideneaceton (3b) with 4-O-benzyldihydroferulic acid chloride (2b) in the presence of NaH-THF.