67287-54-1

Basic information

• Product Name: 6-chloro-2,3,4,5-tetrahydro-7,8-dihydroxy-1-(4-hydroxyphenyl)-1H-3-benzazepinium bromide
• Synonyms: (±)-SKF 82526 HydrobroMide;6-Chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-1H-3-benzazepine-7,8-diol HydrobroMide;SKF 82526 HydrobroMide;6-chloro-2,3,4,5-tetrahydro-7,8-dihydroxy-1-(4-hydroxyphenyl)-1H-3-benzazepinium bromide;FENOLDOPAM MONOHYDROBROMIDE;6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-1h-3-benzazepine-7,8-diol monohydrobromide;FenoldopaM HydrobroMide
• CAS NO: 67287-54-1
• Molecular Formula: BrH*C₁₆H₁₆ClNO₃
• Molecular Weight: 386.67
• EINECS: 266-634-7
• Product Categories: Neurochemicals;Pharmaceuticals;Agonists;Aromatics;Heterocycles;Intermediates & Fine Chemicals
• Mol File: 67287-54-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 522.6°Cat760mmHg
• Flash Point: 269.9°C
• Appearance: off-white/
• Density: 1.38g/cm³
• Vapor Pressure: 1.53E-11mmHg at 25°C
• Storage Temp.: 2-8°C
• Solubility: DMSO: >12mg/mL
• CAS DataBase Reference: 6-chloro-2,3,4,5-tetrahydro-7,8-dihydroxy-1-(4-hydroxyphenyl)-1H-3-benzazepinium bromide(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-2,3,4,5-tetrahydro-7,8-dihydroxy-1-(4-hydroxyphenyl)-1H-3-benzazepinium bromide(67287-54-1)
• EPA Substance Registry System: 6-chloro-2,3,4,5-tetrahydro-7,8-dihydroxy-1-(4-hydroxyphenyl)-1H-3-benzazepinium bromide(67287-54-1)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36-42/43
• Safety Statements: 22-26-36/37/39
• WGK Germany: 3
• Hazardous Substances Data: 67287-54-1(Hazardous Substances Data)

Usage

Uses

Fenoldopam Monohydrobromide is a potent D-1 dopamine agonists.

Biochem/physiol Actions

Fenoldopam is a selective dopamine agonist that is being considered for the parenteral treatment of systemic hypertension. In both an oral and parenteral form, fenoldopam causes peripheral vasodilation by stimulating dopamine-1 adrenergic receptors. Intravenous fenoldopam may provide advantages over sodium nitroprusside because it can induce both a diuresis and natriuresis, is not light sensitive, and is not associated with cyanide toxicity. There is no evidence for rebound hypertension after discontinuation of fenoldopam infusion.

InChI:InChI=1/C16H16ClNO3.BrH/c17-15-11-5-6-18-8-13(9-1-3-10(19)4-2-9)12(11)7-14(20)16(15)21;/h1-4,7,13,18-21H,5-6,8H2;1H

Upstream product

• 67287-53-0 6-chloro-7,8-dimethoxy-1-(4-methoxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 67287-36-9 2-(2-chloro-3,4-dimethoxyphenyl)ethylamine 
• 5417-17-4 2-chloro-3,4-dimethoxybenzaldehyde 
• 93983-14-3 2-chloro-3,4-dimethoxybenzyl chloride 
• 637-69-4 4-Methoxystyrene 
• 621-59-0 isovanillin 
• 75306-60-4 [2-tert-Butoxy-2-(4-methoxy-phenyl)-ethyl]-[2-(2-chloro-3,4-dimethoxy-phenyl)-ethyl]-amine 
• 37687-57-3 2-chloro-3-hydroxy-4-methoxybenzaldehyde 
• 19484-05-0 1-((4-methoxy)phenyl)-1,2-dibromoethane 
• 72912-33-5 2-bromo-1-(tert-butoxy)-1-(4-methoxyphenyl)ethane 
• 74427-18-2 N-(2-chloro-3,4-dimethoxyphenylethyl)-4-methoxymandelamide 
• 93983-13-2 2-chloro-3,4-dimethoxybenzyl alcohol 
• 71636-38-9 N-[2-hydroxy-2-(4'-methoxyphenyl)ethyl]-2-(2-chloro-3,4-dimethoxyphenyl)ethylamine 

Downstream Products

• 67227-56-9 fenoldopam 

Relevant articles and documents

Process for the preparation of Fenoldopam Mesylate

Methods and intermediates for the preparation of Fenoldopam mesylate and intermediates thereof are provided.

Synthesis and renal vasodilator activity of some dopamine agonist 1-aryl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diols: Halogen and methyl analogues of fenoldopam

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