75391-09-2Relevant academic research and scientific papers
Bismuth triflate catalyzed Mukaiyama aldol reaction in an ionic liquid
Ollevier, Thierry,Desyroy, Valerie,Debailleul, Blandine,Vaur, Sophie
, p. 4971 - 4973 (2007/10/03)
We have developed an efficient, bismuth triflate catalyzed Mukaiyama aldol reaction. The reaction proceeds rapidly and affords the corresponding β-hydroxy carbonyl compound in moderate to very good yields (up to 92%). Wiley-VCH Verlag GmbH & Co. KGaA, 200
Crossed aldol-type reactions catalyzed by rhodium complexes
Sato, Susumu,Matsuda, Isamu,Izumi, Yusuke
, p. 223 - 238 (2007/10/02)
Crossed aldol-type reactions of enol trimethylsilyl ethers with aldehydes and ketones are smooth when carried out with a catalytic amount of a rhodium complex, Rh4(CO)12 or X (X=PF6 and ClO4; COD=cycloocta-1,5-diene, DPPB=1,4-bis(diphenylphosphino)butane), under neutral conditions.A suitable catalyst enables the isolation of three different types of aldol reaction product, β-trimethylsiloxy ketones, β-hydroxy ketones, and α,β-unsaturated ketones.Rh4(CO)12 and ClO4 also catalyze the reaction of enol trimethylsilyl ethers with acetals or ketals, whereas PF6 does not.When ClO4 is used as the catalyst, this type of aldol reaction is extended to the one-pot synthesis of trisubstituted furans from enol trimethylsilyl ether and α-trimethylsiloxy acetal.
THE FIRST EXAMPLE OF ALDOL REACTIONS BETWEEN TRIMETHYLSILYL ENOL ETHERS AND ALDEHYDES BY THE AID OF RHODIUM COMPLEX
Sato, Susumu,Matsuda, Isamu,Izumi, Yusuke
, p. 5517 - 5520 (2007/10/02)
Crossed aldol reaction of trimethylsilyl enol ether with aldehyde is successfully performed with the aid of catalytic amount of rhodium complex, +X- (X = PF6 and ClO4) or Rh4(CO)12, under neutral conditions.
Lithium Iodide-promoted Aldol Condensation Reactions
Kelleher, Roger G.,McKervey, M. Anthony,Vibuljan, Pongsak
, p. 486 - 488 (2007/10/02)
Anhydrous lithium iodide in ether, tetrahydrofuran, or benzene is an effective reagent for the formation of α,β-unsaturated ketones by condensation of alkyl ketones with enolisable and non-enolisable aldehydes; in the presence of trimethylchlorosilane-triethylamine enone formation is suppressed and high yields of 1,3-hydroxyketones are obtained as their trimethylsilyl ether derivatives.
