75400-59-8Relevant academic research and scientific papers
Suzuki Coupling of Amides via Palladium-Catalyzed C–N Cleavage of N-Acylsaccharins
Wu, Hongxiang,Li, Yue,Cui, Ming,Jian, Junsheng,Zeng, Zhuo
, p. 3876 - 3880 (2016/12/16)
A palladium-catalyzed cross-coupling of activated amides with arylboronic acids has been developed via C–N bond cleavage. This approach demonstrated high tolerance to a variety of alkyl, aryl, heterocyclic and vinyl substituents. Unsymmetrical ketones could be achieved in excellent yield under mild conditions with 1% catalyst loadings. (Figure presented.).
Zinc-mediated acylation and sulfonation of pyrrole and its derivatives
Yadav,Reddy,Kondaji,Srinivasa Rao,Praveen Kumar
, p. 8133 - 8135 (2007/10/03)
Pyrrole and its derivatives react smoothly with acid chlorides and sulfonyl chlorides in the presence of zinc metal in toluene at ambient temperature to afford the corresponding 2-acetyl and 2-sulfonyl pyrrole derivatives in high yields with high regioselectivity.
Synthesis and Reactions of N-Protected 2-Lithiated Pyrroles and Indoles. The tert-Butoxycarbonyl Substituent as a Protecting Group
Hasan, Iltifat,Marinelli, Edmund R.,Lin, Li-Ching Chang,Fowler, Frank W.,Levy, Alan B.
, p. 157 - 164 (2007/10/02)
N-(tert-Butoxycarbonyl)pyrrole and N-(tert-butoxycarbonyl)indole have been prepared and lithiated at the 2-position with lithium 2,2,6,6-tetramethylpiperidide and tert-butyllithium, respectively.These lithium reagents react with a variety of electrophiles to give the 2-substituted N-(tert-butoxycarbonyl)pyrroles and N-(tert-butoxycarbonyl)indoles.The N-(tert-butoxycarbonyl) substituent may be removed rapidly and in high yield from the pyrrole derivatives under basic conditions.For the indole derivatives, the protecting group may be removed with either acidic or basic conditions.
