754215-63-9Relevant academic research and scientific papers
Carbon glycoside compound as well as preparation and application thereof
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Paragraph 0051-0053, (2020/12/30)
The invention discloses a carbon glycoside compound as well as preparation and application thereof, and particularly relates to a carbon glycoside compound as shown in a general formula (I), a preparation method of the carbon glycoside compound, and application of a pharmaceutical composition containing the compound in inhibiting sodium-dependent glucose transporter 2, SGLT-2 and the application in preparation of drugs for treating and preventing diabetes and complications.
Facile synthesis of acacetin and its derivatives
Zhao, Yuan,Cai, Li,Sui, Qiang,Lin, Feng,Jiang, Wen,Chen, Jianli,Lu, Weigeng,Gao, Qi
supporting information, p. 3577 - 3580 (2016/07/21)
Acacetin, a O-methylated bioflavonoid isolated from the traditional Chinese medicine Xuelianhua (Saussurea tridactyla), is a promising orally effective atrium-selective antiarrhythmic agent for the treatment of atrial fibrillation (AF). Here we describe an efficient two-component method for the synthesis of acacetin and its derivatives.
Total synthesis of 3′,3?-binaringenin and related biflavonoids
Sagrera, Gabriel,Seoane, Gustavo
scheme or table, p. 2776 - 2786 (2010/10/19)
The synthesis of natural 3++,3?-binaringenin and four related biflavonoids was performed in good overall yield (15-35%) starting from readily available phloroglucinol and 4-hydroxy- or 4-methoxybenzaldehyde. Preliminary results indicate that some of these compounds have an interesting activity against S. aureus. Georg Thieme Verlag Stuttgart.
Hydrogenation of substituted aromatic aldehydes: Nucleophilic trapping of the reaction intermediate, application to the efficient synthesis of methylene linked flavanol dimers
Boyer, Fran?ois-Didier,Ducrot, Paul-Henri
, p. 5177 - 5180 (2007/10/03)
The synthesis of dimeric flavanols is the consequence of the possible trapping of the reaction intermediates generated in the course of the reductive hydrogenation of substituted benzaldehydes. The scope of this reaction is investigated.
Buffer-induced, selective mono-C-alkylation of phloroglucinol: Application to the synthesis of an advanced intermediate of catechin
Gissot, Arnaud,Wagner, Alain,Mioskowski, Charles
, p. 6807 - 6812 (2007/10/03)
A straightforward mono-selective and C-specific alkylation of phloroglucinol with activated alkyl halides is presented. The use of water as solvent limits the amount of over-alkylated by-products. Provided some minor changes in the experimental conditions, hydrophobic cinnamyl halides can also be reacted, thus giving a direct access to advanced intermediates of natural flavonoids.
