75424-70-3

Basic information

• Product Name: 2-isopropoxynicotinonitrile
• Synonyms: 2-isopropoxynicotinonitrile;2-isopropoxynicotinonitrile(SALTDATA: FREE)
• CAS NO: 75424-70-3
• Molecular Formula: C9H10N2O
• Molecular Weight: 162.1885
• Mol File: 75424-70-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-isopropoxynicotinonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-isopropoxynicotinonitrile(75424-70-3)
• EPA Substance Registry System: 2-isopropoxynicotinonitrile(75424-70-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 75424-70-3(Hazardous Substances Data)

Upstream product

• 75-30-9 2-iodo-propane 
• 20577-27-9 pyrid-2-one-3-carbonitrile 
• 915787-96-1 2-isopropoxy-nicotinic acid amide 
• 144-55-8 sodium hydrogencarbonate 
• 76-02-8 trifluoroacetyl chloride 
• 6602-54-6 2-chloro-3-pyridinecarbonitrile 
• 67-63-0 isopropyl alcohol 

Downstream Products

• 851773-48-3 (2-isopropoxy-pyridin-3-yl)-methylamine 

Relevant articles and documents

Mild and Regioselective N-Alkylation of 2-Pyridones in Water

A mild and regioselective N-alkylation reaction of 2-pyridones in water has been developed. Tween 20 (2% w/w) was added to create a micellar system for improved solubility of starting materials, which leads to enhanced reaction rates. The protocol demonstrated a wide substrate scope with good isolated yields (40-94%) for all of the 24 examples evaluated. High regioselectivity favoring N-alkylation over O-alkylation was observed for benzyl halides (>5:1), primary alkyl halides (>6:1), and bulky and less reactive secondary alkyl halides (>2.4:1).

PYRAZOLE COMPOUND AND THERAPEUTIC AGENT FOR DIABETES COMPRISING THE SAME

A pyrazole compound represented by the general formula (I) or a salt thereof which has a hepatic glycogen phosphorylase inhibitory activity and therefore is useful as a therapeutic or prophylactic agent for diabetes or a pharmacologically salt thereof : wherein the ring Q represents an aryl group or an aromatic heterocyclic group; R1 represents a hydrogen atom, a halogen atom, a C1-6 alkyl group or a C1-6 alkoxy group; R2 represents a halogen atom, a C1-6 alkyl group, a C1-6 alkoxy group or an azide group; R3 represents a halogen atom, a hydroxyl group, a C1-6 alkyl group, a halo-C1-6 alkyl group, a C1-6 alkoxy group, an azide group, an amino group, an acylamino group or a C1-6 alkylsulfonylamino group; R4 and R5 independently represent a hydrogen atom, a C1-6 alkyl group which may be substituted, a a C3-8 cycloalkyl group, a saturated heterocyclic group which may be substituted, an aryl group which may be substituted, a C7-14 aralkyl group, an aromatic heterocyclic group or the like.

Phase-Transfer Mediated Heteroaromatic Nucleophilic Substitution: Introduction of a β-Adrenergic Blocking Moiety

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