75487-82-0

Upstream product

• 223778-71-0 ethyl 3-(5'-fluoro-2'-methoxyphenyl)-2-propenoate 
• 64-18-6 formic acid 
• 91-64-5 coumarin 
• 371-41-5 4-Fluorophenol 
• 617-48-1 malic acid 
• 141-82-2 malonic acid 
• 347-54-6 5-fluoro-2-hydroxybenzaldehyde 
• 4279-77-0 S-phenyl hydrogen thiomalonate 
• 108-24-7 acetic anhydride 
• 949449-09-6 3-(5-fluoro-2-hydroxyphenyl)acrylic acid ethyl ester 
• 108-31-6 maleic anhydride 
• 452-08-4 2-bromo-4-fluoro-1-methoxybenzene 

Relevant academic research and scientific papers

Synthesis, characterization, optical properties and theoretical calculations of 6-fluoro coumarin

6-Fluoro coumarin is synthesized and characterized by 1H NMR and 13C NMR. The optical properties of the title compound are investigated by UV-vis absorption and fluorescence emission spectra, the results show the title compound can a

Fe(III)-Catalyzed Decarboxylative C3-Difluoroarylmethylation of Coumarins with α,α-Difluoroarylacetic Acids

A facile Fe(III)-catalyzed oxidative decarboxylative radical coupling reaction of α,α-difluoroarylacetic acids with coumarins has been developed. This transformation, which provides a series of C-3 difluoroarylmethylated coumarins containing various functional groups in moderate-to-good yields, features easily accessible starting materials and operational simplicity.

Visible-light-induced regioselective alkylation of coumarins via decarboxylative coupling with N-hydroxyphthalimide esters

An efficient photocatalytic decarboxylative 3-position alkylation of coumarins by using alkyl N-hydroxyphthalimide esters as alkylation reagents has been developed. A variety of NHP esters derived from aliphatic carboxylic acids (primary, secondary, and tertiary) has been proved to be tolerated for this decarboxylation process, affording a broad scope of 3-alkylated coumarin derivatives in moderate to excellent yields. This protocol was highlighted by its mild conditions, readily available starting materials, operational simplicity, and wide functional group tolerance.

Synthesis method for coumarins compound

The invention discloses a synthesis method for a coumarins compound. The structural formula is shown in the specification, wherein R1 is selected from one or more of -H, -CH3, -OCH3, -F, -Cl, -Br, -OH, -NO2 and N(CH2CH3)2 and R2 is selected from one of -H, -CH3 or CH2CH3. According to the invention, a 2-hydroxy cinnamate compound is directly utilized as a raw material and the coumarins compound is synthesized in one step under the catalytic effect of visible light. Compared with the present synthesis method, the synthesis method for the coumarins compound disclosed by the invention has the characteristics of simple method, mild condition and high yield; the reaction is carried out under normal temperature; and the visible light is utilized as a reaction energy source and is green and pollution-free.

Amine-catalyzed cascade synthesis of 3,4-diunsubstituted coumarins

We disclose an efficient route to synthesize 3,4-diunsubstituted coumarins through a cascade organocatalytic reaction. The reaction is catalyzed by using of a combination of benzylamine (10 mol-%) and triethylamine (10 mol-%). Various salicylaldehydes were tested, and the corresponding coumarin products were obtained in good to high yields under mild and metal-free reaction conditions. We disclose an efficient route to synthesize 3,4-diunsubstituted coumarins through a cascade organocatalytic reaction. The reaction is catalyzed by using of a combination of benzylamine (10 mol-%) and triethylamine (10 mol-%). Various salicylaldehydes are tested, and the corresponding coumarin products are obtained in good to high yields under mild and metal-free reaction conditions. Copyright

COUMARIN-BASED COMPOUNDS

Compounds including those of the Formula I where X, R1, R2 and subscript t are as defined herein, useful as γ-secretase inhibitors, are provided, as are compositions comprising the compounds, as well as methods for use of the compoun

Direct fluorination of coumarin, 6-methyl-coumarin and 7-alkoxy-coumarins

Direct fluorination of coumarin in acid media led to complex mixtures of products arising from electrophilic substitution processes. Fluorination of 6-methyl- and 7-alkoxy-coumarins was, however, more selective and preparatively useful quantities of various fluorinated systems were obtained.

An efficient large scale synthesis of coumarins by a dealkylative boron- mediated ring closure of 3-(ortho-methoxyaryl)propenoic esters

Various substituted coumarins 3 were prepared via a dealkylative boron- mediated ring closure of ortho-methoxycinnamates 2.

Fluoro coumarins as antilymphoedema agents

A compound of the formula STR1 wherein hydrogen, fluorine, chlorine or bromine; B is fluorine, or when A is fluorine B may be hydrogen; R is hydrogen, C1 -C8 branched or unbranched alkyl, CH2 BR, CH2 Cl or substituted or unsubstituted phenyl; X is hydrogen, chlorine or bromine; one of R1 and R2 is hydrogen and the other is hydroxy or C1 -C7 branched or unbranched alkoxy unsubstituted or substituted by a dialkyl amino group, or R1 and R2, taken together with the carbon atom to which they are linked, form the group STR2 with the proviso that, when R and X are both hydrogen, STR3 is a STR4 group, and B is fluorine and A is hydrogen is useful as antilimphoedema agent.