755027-21-5

Basic information

• Product Name: 5-CHLORO-2-IODOANISOLE
• Synonyms: 5-CHLORO-2-IODOANISOLE;4-Chloro-1-iodo-2-methoxybenzene;5-Chloro-2-iodoanisole97%
• CAS NO: 755027-21-5
• Molecular Formula: C₇H₆ClIO
• Molecular Weight: 268.476
• Product Categories: Anisoles, Alkyloxy Compounds & Phenylacetates;Chlorine Compounds;Iodine Compounds
• Mol File: 755027-21-5.mol
• Article Data: 10

Chemical Properties

• Melting Point: 20℃
• Boiling Point: 269℃
• Flash Point: 117℃
• Appearance: /
• Density: 1.820
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 5-CHLORO-2-IODOANISOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-2-IODOANISOLE(755027-21-5)
• EPA Substance Registry System: 5-CHLORO-2-IODOANISOLE(755027-21-5)

Safety Data

• Hazardous Substances Data: 755027-21-5(Hazardous Substances Data)

Usage

General Description

5-CHLORO-2-IODOANISOLE is a chemical compound with the molecular formula C7H6ClIO. It is a halogenated anisole, which is a type of aromatic ether. This chemical is commonly used as a building block in organic synthesis and pharmaceutical research, due to its ability to undergo various reactions like halogenation, arylation, and cross-coupling. It is known for its strong and distinct odor, and it is also utilized as a starting material in the production of agrochemicals, fragrances, and dyes. 5-CHLORO-2-IODOANISOLE is considered a hazardous chemical and should be handled with caution, as it may cause skin and eye irritation upon contact.

InChI:InChI=1S/C7H6ClIO/c1-10-7-4-5(8)2-3-6(7)9/h2-4H,1H3

Upstream product

• 529-28-2 4-iodoanisol 
• 57479-70-6 2-methoxy-4-chlorobenzoic acid 
• 136808-72-5 2-iodo-5-chlorophenol 
• 74-88-4 methyl iodide 
• 6627-53-8 1-chloro-3-methoxy-4-nitrobenzene 
• 2845-89-8 1-chloro-3-methoxy-benzene 
• 118700-33-7 2-dichloroiodanyl-anisole 
• 93-50-5 4-chloro-o-anisidine 

Downstream Products

• 1268238-62-5 (E)-4-chloro-1-(3-(4-chloro-2-methoxyphenyl)allyl)-2-methoxybenzene 
• 60207-19-4 1-(4-chloro-2-methoxyphenyl)-ethanone 
• 100960-68-7 4-chloro-2-methoxylbenzonitrile 
• 52807-06-4 1-(2,4'-Dichloro-2'-methoxy-biphenyl-4-yl)-ethanone 
• 905816-06-0 1-{2-[5-chloro-2-(3-fluoro-phenylsulfanyl)-phenoxy]-ethyl}-pyrrolidine-2-carboxylic acid tert-butyl ester 
• 905815-97-6 2-[5-chloro-2-(3-fluoro-phenylsulfanyl)-phenoxy]-ethanol 
• 791642-72-3 5-chloro-2-(3-fluoro-phenylsulfanyl)-phenol 
• 791642-71-2 4-chloro-1-(3-fluoro-phenylsulfanyl)-2-methoxybenzene 

Relevant articles and documents

Pd-Catalyzed ipso, meta-Dimethylation of ortho-Substituted Iodoarenes via a Base-Controlled C-H Activation Cascade with Dimethyl Carbonate as the Methyl Source

A methyl group can have a profound impact on the pharmacological properties of organic molecules. Hence, developing methylation methods and methylating reagents is essential in medicinal chemistry. We report a palladium-catalyzed dimethylation reaction of ortho-substituted iodoarenes using dimethyl carbonate as a methyl source. In the presence of K2CO3 as a base, iodoarenes are dimethylated at the ipso- and meta-positions of the iodo group, which represents a novel strategy for meta-C-H methylation. With KOAc as the base, subsequent oxidative C(sp3)-H/C(sp3)-H coupling occurs; in this case, the overall transformation achieves triple C-H activation to form three new C-C bonds. These reactions allow expedient access to 2,6-dimethylated phenols, 2,3-dihydrobenzofurans, and indanes, which are ubiquitous structural motifs and essential synthetic intermediates of biologically and pharmacologically active compounds.

NEW COMPOUND HAVING FGFR INHIBITORY ACTIVITY AND PREPARATION AND APPLICATION THEREOF

The present invention relates to a new compound having an FGFR inhibitory activity and preparation and application thereof. In particular, the compound according to the present invention has a structure as shown in formula I, wherein each group and substituent are as defined in the description. Also disclosed in the present invention are a preparation method for the compound and a use thereof in preparation of a drug for treating and/or preventing a tumor-related disease and/or an FGFR-related disease.

Mild and selective organocatalytic iodination of activated aromatic compounds

We describe an organocatalytic iodination of activated aromatic compounds using 1,3-diiodo-5,5-dimethylhydantoin (DIH) as the iodine source with thiourea catalysts in acetonitrile. The protocol is applicable to a number of aromatic substrates with significantly different steric and electronic properties. The iodination is generally highly regioselective and provides high yields of isolated products. NMR kinetic investigations conducted in THF-d 8indicate the role of sulfur in the thiourea motif as a nucleophile that is assisted by H-bonding in the key steps of the reaction. Georg Thieme Verlag Stuttgart . New York.