75513-47-2

Upstream product

• 83030-52-8 2-Bromo-1-(4-methoxy-benzyloxy)-4-(2-nitro-ethyl)-benzene 
• 83030-50-6 1-[3-Bromo-4-(4-methoxy-benzyloxy)-phenyl]-2-nitro-ethanol 
• 98489-01-1 2-(3-bromo-4-hydroxyphenyl)ethylamine 
• 80314-46-1 (S)-7-Bromo-9-(2,6-dibromo-4-{2-[(E)-hydroxyimino]-2-methoxycarbonyl-ethyl}-phenoxy)-8-oxo-1-oxa-2-aza-spiro[4.5]deca-2,6,9-triene-3-carboxylic acid methyl ester 
• 937678-86-9 4-(4-methoxybenzyloxy)-3-bromobenzaldehyde 
• 2973-78-6 3-bromo-4-hydroxybenzylaldehyde 
• 83047-64-7 bis-p-methoxybenzyl bastadin-2 
• 83030-53-9 3-bromotyramine p-methoxybenzyl ether 
• 83030-41-5 (E)-methyl 3-(3,5-dibromo-4-hydroxyphenyl)-2-(hydroxyimino)propanoate 
• 83030-42-6 3-[3-Bromo-5-(2,6-dibromo-4-{2-[(E)-hydroxyimino]-2-methoxycarbonyl-ethyl}-phenoxy)-4-hydroxy-phenyl]-2-[(E)-hydroxyimino]-propionic acid methyl ester 
• 83030-51-7 2-Bromo-1-(4-methoxy-benzyloxy)-4-((E)-2-nitro-vinyl)-benzene 

Downstream Products

• 75513-52-9 N-[2-(3-Bromo-4-methoxy-phenyl)-ethyl]-3-[3,5-dibromo-4-(3-bromo-5-{2-[2-(3-bromo-4-methoxy-phenyl)-ethylcarbamoyl]-2-[(E)-methoxyimino]-ethyl}-2-methoxy-phenoxy)-phenyl]-2-[(Z)-methoxyimino]-propionamide 
• 75513-52-9 bastadin-2 pentamethyl ether 

Relevant academic research and scientific papers

Total synthesis of bastadins 2, 3, and 6

A chemoenzymatic strategy has been developed for the synthesis of bastadins 2, 3, and 6. The requisite dimeric dityrosine and isodityrosine building blocks were successfully prepared by oxidative C - C and C - O phenolic coupling of mono- and dihalogenated derivatives of tyrosine and tyramine using horseradish and soybean peroxidases. By carefully controlling the experimental parameters, the requisite synthons may now be prepared in synthetically useful yields without the exhaustive protection and deprotection of the sensitive functional groups.

TOTAL SYNTHESIS OF BASTADINS

Bastadins-1, -2 and -3, the novel metabolites originated from four bromotyrosine units, were synthesized, and each geometry at the oxime C=N double bonds was unambiguously determined to be anti.