7552-71-8

Basic information

• Product Name: Benzene, 1-(phenylmethyl)-2-(trifluoromethyl)-
• CAS NO: 7552-71-8
• Molecular Formula: C14H11F3
• Molecular Weight: 236.237
• Mol File: 7552-71-8.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(phenylmethyl)-2-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(phenylmethyl)-2-(trifluoromethyl)-(7552-71-8)
• EPA Substance Registry System: Benzene, 1-(phenylmethyl)-2-(trifluoromethyl)-(7552-71-8)

Safety Data

• Hazardous Substances Data: 7552-71-8(Hazardous Substances Data)

Upstream product

• 395-44-8 o-trifluoromethylbenzyl bromide 
• 98-80-6 phenylboronic acid 
• 201230-82-2 carbon monoxide 
• 1423-27-4 2-(trifluoromethyl)phenylboronic acid 
• 100-44-7 benzyl chloride 
• 108-86-1 bromobenzene 
• 346-06-5 (2-(trifluoromethyl)phenyl)methanol 
• 392-83-6 o-trifluoromethylphenyl bromide 
• 89523-63-7 benzylzinc chloride 
• 55810-66-7 2-(benzyl)benzoyl chloride 
• 612-35-1 2-Benzylbenzoic acid 
• 29921-41-3 (o-benzyl)chlorobenzene 
• 120120-26-5 (trifluoromethyl)triethylsilane 
• 5281-18-5 benzaldehyde, hydrazone 

Downstream Products

• 120-12-7 anthracene 
• 713-36-0 2-benzyltoluene 
• 52103-77-2 4a,9,9a,10-tetrahydroanthracene 
• 613-31-0 9,10-dihydroanthracene 

Relevant articles and documents

Nickel-catalyzed cross-coupling of aldehydes with aryl halides: Via hydrazone intermediates

Traditional cross-couplings require stoichiometric organometallic reagents. A novel nickel-catalyzed cross-coupling reaction between aldehydes and aryl halides via hydrazone intermediates has been developed, merging the Wolff-Kishner reduction and the classical cross-coupling reactions. Aromatic aldehydes, aryl iodides and aryl bromides are especially effective in this new cross-coupling chemistry.

Pd-Catalyzed Decarbonylative Cross-Couplings of Aroyl Chlorides

This report describes a method for Pd-catalyzed decarbonylative cross-coupling that enables the conversion of carboxylic acid derivatives to biaryls, aryl amines, aryl ethers, aryl sulfides, aryl boronate esters, and trifluoromethylated arenes. The success of this transformation leverages the Pd0/Brettphos-catalyzed decarbonylative chlorination of aroyl chlorides, which can then participate in diverse cross-coupling reactions in situ using the same Pd catalyst.

Cobalt co-catalysis for cross-electrophile coupling: Diarylmethanes from benzyl mesylates and aryl halides

The nickel-catalyzed cross-coupling of aryl halides with alkyl radicals derived from alkyl halides has recently been extended to couplings with carbon radicals generated by a co-catalyst. In this study, a new co-catalyst, cobalt phthalocyanine (Co(Pc)), is introduced and demonstrated to be effective for coupling substrates not prone to homolysis. This is because Co(Pc) reacts with electrophiles by an SN2 mechanism instead of by the electron-transfer or halogen abstraction mechanisms previously explored. Studies demonstrating the orthogonal reactivity of (bpy)Ni and Co(Pc), applying this selectivity to the coupling of benzyl mesylates with aryl halides, and the adaptation of these conditions to the less reactive benzyl phosphate ester and an enantioconvergent reaction are presented.