2252-84-8

Basic information

• Product Name: 1H-HEPTAFLUOROPROPANE
• Synonyms: 1,1,1,2,2,3,3-Heptafluoropropane;1H-Perfluoropropane;1-Hydroheptafluoropropane;C2F5CF2H;Freon227ca;FC-227CA;1H-HEPTAFLUOROPROPANE;1H-Heptafluoropropane (FC-227ca)
• CAS NO: 2252-84-8
• Molecular Formula: C₃HF₇
• Molecular Weight: 170.03
• Product Categories: refrigerants
• Mol File: 2252-84-8.mol

Chemical Properties

• Melting Point: -126.8°C (estimate)
• Boiling Point: -16,3°C
• Appearance: /
• Density: 1.4710 (estimate)
• Vapor Pressure: 3080mmHg at 25°C
• Refractive Index: 1.2747 (estimate)
• CAS DataBase Reference: 1H-HEPTAFLUOROPROPANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-HEPTAFLUOROPROPANE(2252-84-8)
• EPA Substance Registry System: 1H-HEPTAFLUOROPROPANE(2252-84-8)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 23-38
• RIDADR: 3296
• HazardClass: GAS
• Hazardous Substances Data: 2252-84-8(Hazardous Substances Data)

Usage

Uses

Used in Refrigeration Industry:
1H-HEPTAFLUOROPROPANE is used as a refrigerant for its non-flammable, non-toxic, and environmentally friendly characteristics. It is an effective alternative to traditional refrigerants, such as chlorofluorocarbons (CFCs) and hydrochlorofluorocarbons (HCFCs), which have been phased out due to their harmful effects on the ozone layer and global warming potential.
Used in Fire Suppression Systems:
Due to its non-flammable nature and ability to displace air, 1H-HEPTAFLUOROPROPANE is used as a fire suppressant in certain fire suppression systems. It helps to extinguish fires by reducing the oxygen concentration in the affected area, thus preventing the fire from spreading.
Used in Aerosol Propellants:
1H-HEPTAFLUOROPROPANE is also used as a propellant in aerosol products, such as personal care items, cleaning products, and medical applications. Its non-toxic and non-flammable properties make it a safe and effective choice for these applications.
Used in High-Voltage Circuit Breakers:
In the electrical industry, 1H-HEPTAFLUOROPROPANE is utilized as an insulating and arc-quenching medium in high-voltage circuit breakers. Its non-flammable and non-toxic properties contribute to the safety and efficiency of these electrical components.
Used in Industrial Applications:
1H-HEPTAFLUOROPROPANE is employed in various industrial processes, such as heat transfer systems, power generation, and chemical reactions, due to its non-flammable, non-toxic, and stable nature. It provides an efficient and environmentally friendly solution for these applications.

Synthesis Reference(s)

Journal of the American Chemical Society, 73, p. 4054, 1951 DOI: 10.1021/ja01152a548

Reactivity Profile

Halogenated aliphatic compounds, such as 1H-HEPTAFLUOROPROPANE, are moderately or very reactive. Reactivity generally decreases with increased degree of substitution of halogen for hydrogen atoms. Materials in this group may be incompatible with strong oxidizing and reducing agents. Also, they may be incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides.

Health Hazard

Vapors may cause dizziness or asphyxiation without warning. Vapors from liquefied gas are initially heavier than air and spread along ground. Contact with gas or liquefied gas may cause burns, severe injury and/or frostbite. Fire may produce irritating, corrosive and/or toxic gases.

Fire Hazard

Some may burn but none ignite readily. Containers may explode when heated. Ruptured cylinders may rocket.

InChI:InChI=1/C3HF7/c4-1(5)2(6,7)3(8,9)10/h1H

Upstream product

• 375-22-4 heptafluorobutyric Acid 
• 107-92-6 butyric acid 
• 754-34-7 1,1,1,2,2,3,3-heptafluoro-3-iodo-propane 
• 106-47-8 4-chloro-aniline 
• 662-50-0 heptafluorobutyramide 
• 123-91-1 1,4-dioxane 
• 116-14-3 polytetrafluoroethylene 
• 75-46-7 trifluoromethan 
• 756-18-3 bis-heptafluoropropyl-iodo-phosphine 
• 423-25-6 (heptafluoro n-propyl) magnesiumiodide 
• 375-00-8 heptafluorobutyronitrile 
• 60-29-7 diethyl ether 
• 677-22-5 tert-butylmagnesium chloride 
• 693-04-9 butyl magnesium bromide 

Downstream Products

• 75-73-0 carbon tetrafluoride 
• 76-19-7 freon-218 
• 76-16-4 Hexafluoroethane 
• 785-93-3 1-phenyl-2,2,3,3,4,4,4-heptafluorobutan-1-ol 
• 2117-94-4 butylboronic acid dimethyl ester 
• 6867-35-2 lithium tetramethanolatoborate 
• 354-34-7 trifluoroacetyl fluoride 
• 422-61-7 perfluoropropanoyl fluoride 
• 422-85-5 perfluoropropyl bromide 
• 3170-79-4 heptafluoropropyl 
• 353-50-4 Carbonyl fluoride 
• 3369-48-0 pentafluoroethyl radical 
• 1511-62-2 bromodifluoromethane 
• 661-95-0 1,2-dibromohexafluoropropane 

Relevant articles and documents

Photochemistry of Anhydrides Part 4.-Photolysis of Perfluoro-n-butyric Anhydride Reaction of n-C3F7 Radicals with Cyclohexane

The photolysis of the vapour of perfluoro-n-butyric anhydride was studied at 20 and 227 deg C.The effective primary process is (n-C3F7CO)2O+hυ -> 2 n-C3F7+CO+CO2 and the overall decomposition is quantitatively described by the equation (n-C3F7CO)2O+hυ -> n-C6F14+CO+CO2.The quantum yields of products increase with temperature but are independent of pressure. (n-C3F7CO)2O was photolysed in the presence of cyclohexane vapour.For the reactions n-C3F7+c-C6H12 -> n-C3F7H+c-C6H11 kH 2n-C3F7 -> C6F14 kc we obtain, log kH/k1/2c = (4.99+/-0.12)-(23910+/-750)/Θ where Θ = 2.303RTJmol-1 and kH/k1/2c is in cm1/2mol-1/2s-1/2.

HETEROCYCLIC POLYFLUORO-COMPOUNDS. PART 35. DEHYDROFLUORINATION OF 2,2-BIS(TRIFLUOROMETHYL)- AND 2-PERFLUOROALKYL-3,4-DIFLUORO-OXETANS

Solid potassium hydroxide dehydrofluorinates 2,2-bis-(trifluoromethyl)-3,4-difluoro-oxetan to 3-fluoro-4,4-bis-(trifluoromethyl)-2-oxete (59percent), 2-pentafluoroethyl-3,4-difluoro-oxetan to 2-tetrafluoroethylidene-3,4-difluoro-oxetan, and r-2-heptafluoro-n-propyl-t-3,t-4-difluoro-oxetan to (Z)-2-hexafluoro-n-propylidene-cis-3,4-difluoro-oxetan.Factors which affect these reactions are discussed.

Perfluoroalkyl Grignard Reagents: NMR Study of 1-Heptafluoropropylmagnesium Chloride in Solution

We report on the generation of a perfluoroalkyl Grignard reagent (FRMgX) by exchange reaction between a perfluoroalkyl iodide (FR-I) and a Grignard reagent (RMgX). 19F NMR was applied to monitor the generation of n-C3F7MgCl. Additional NMR techniques, including 19F COSY, NOESY, and pulsed gradient spin-echo (PGSE) diffusion NMR, were invoked to assign peaks observed in 19F spectrum. Schlenk equilibrium was observed and was significantly influenced by solvent, diethyl ether, or THF.

METHOD AND APPARATUS FOR CONTINUOUSLY PRODUCING 1,1,1,2,3-PENTAFLUOROPROPANE WITH HIGH YIELD

A method and apparatus for method of continuously producing 1,1,1,2,3-pentafluoropropane with high yield is provided. The method includes (a) bringing a CoF3-containing cobalt fluoride in a reactor into contact with 3,3,3-trifluoropropene to produce a CoF2-containing cobalt fluoride and 1,1,1,2,3-pentafluoropropane, (b) transferring the CoF2-containing cobalt fluoride in the reactor to a regenerator and bringing the transferred CoF2-containing cobalt fluoride into contact with fluorine gas to regenerate a CoF3-containing cobalt fluoride, and (c) transferring the CoF3-containing cobalt fluoride in the regenerator to the reactor and employing the transferred CoF3-containing cobalt fluoride in Operation (a). Accordingly, the 1,1,1,2,3-pentafluoropropane can be continuously produced with high yield from the 3,3,3-trifluoropropene using a cobalt fluoride (CoF2/CoF3) as a fluid catalyst, thereby improving the reaction stability and readily adjusting the optimum conversion rate and selectivity.

Compositions

A composition comprising HCFO-1233xf and at least one additional compound selected from the group consisting of HCFO-1233zd, HCFO-1232xd, HCFO-1223xd, HCFC-253fb, HCFC-233ab, HFO-1234yf, HFO-1234ze, ethylene, HFC-23, CFC-13, HFC-143a, HFC-152a, HFO-1243zf, HFC-236fa, HCO-1130, HCO-1130a, HFO-1336, HCFC-244bb, HCFC-244db, HFC-245fa, HFC-245cb, HCFC-133a, HCFC-254fb, HCFC-1131, HCFO-1242zf, HCFO-1223xd, HCFC-233ab, HCFC-226ba, and HFC-227ca.

Me3SiCF3/AgF/Cu - A new reagents combination for selective trifluoromethylation of various organic halides by trifluoromethylcopper, CuCF3

An alternative copper halide-free route to obtain highly reactive trifluoromethylcopper species has been developed via the reaction of silver fluoride and trimethyl(trifluoromethyl)silane followed by a redox transmetallation with elemental copper. The composition of the reactive intermediate was investigated by means of UV/Vis/NIR, ESR, 19F NMR spectroscopy and ESI mass spectrometry. "Trifluoromethylcopper" prepared by the oxidative transmetallation route exhibits excellent reactivity and selectivity in substitutions of iodine or bromine bond to aromatic or heterocyclic compounds for trifluoromethyl groups without any additional catalyst.

PROCESSES FOR THE PRODUCTION OF FLUOROPROPANES AND HALOPROPENES

A process is disclosed for making CF3CF2CH3, CF3CF=CH2 and/or CF3CCI=CH2. The process involves reacting at least one starting material selected from the group consisting of halopropanes of the formula CX3CH2CH2X, halopropenes of the formula CX3CH=CH2 and halopropenes of the formula CX2=CHCH2X, wherein each X is independently F or Cl, with HF and CI2 in a reaction zone to produce a product mixture comprising HF, HCI, CF3CF2CH3, CF3CF=CH2, and CFsCCI=CH2; and recovering the CF3CF2CH3, CF3CF=CH2 and/or CFsCCI=CH2 from the product mixture. Also disclosed is a process for making CF3CH2CHF2, CFsCH=CHF, and/or CFaCH=CHCI. This process involves reacting at least one starting material selected from the group consisting of halopropenes of the formula CX3CH=CH2 and halopropenes of the formula CX2=CHCH2X, wherein each X is independently F or Cl, with HF and CI2 in a reaction zone to produce a product mixture comprising HF, HCI, CF3CH2CHF2, CFsCH=CHF and CF3CH=CHCI; and recovering the CF3CH2CHF2, CFsCH=CHF, and/or CF3CH=CHCI from the product mixture. The molar ratio of HF to the total amount of starting materials fed to the reaction zone for both of these processes is at least stoichiometric, and the molar ratio of Cl2 to total amount of starting material fed to the reaction zone for both of these processes is 2:1 or less.

Reactions of epoxides derived from internal perfluoroolefins with o-phenylenediamine and 2-aminophenol

The reactions of epoxy derivatives of internal perfluoroolefins with o-phenylenediamine and 2-aminophenol in dioxane gave 23-67% of the corresponding 2,3-bis(perfluoroalkyl)quinoxalines and 2,3-bis-(perfluoroalkyl)-2H-1,4- benzoxazin-2-ols, respectively. When N,N-dimethylacetamide was used as a solvent, the main reaction pathway was anionic isomerization of epoxides into ketones which were then converted into 2-perfluoroalkylbenzimidazoles (in the reactions with o-phenylenediamine) or 2-hydroxy-N-perfluoroalkanoylanilines (in the reactions with 2-aminophenol). The reaction of 3,4-epoxydodecafluorohexane with 2-aminophenol in N,N-dimethylacetamide was accompanied by unusual cyclization to afford 2-pentafluoropropanoyl-2-pentafluoroethyl-1,3- benzoxazolidine. Pleiades Publishing, Inc., 2006.

Fluorine chemistry - Wittig based synthesis of volatile organofluorine compounds

A simple and practical method has been developed for the synthesis and characterization of several interesting classes of volatile organofluorine compounds from fluorophosphonium salts via their in situ generated corresponding ylides. The fluorinated phosphonium ylides react with hexafluoroacetone in DMF to generate perfluoroisobutylene, whereas in the presence of bromine or iodine containing electrophiles, tetrafluoroethylene, perfluoro-2-butene, perfluorocyclobutane, and 1H-heptafluoropropane are obtained.

Addition of some unreactive fluoroalkanes to tetrafluoroethylene.: Direct catalytic synthesis of F-butene-2

Condensation of trifluoromethanes, CF3X (X=H, Cl, Br, I), with tetrafluorethylene to form the corresponding F-n-propyl adducts have been carried out with aluminum chlorofluoride as catalyst. Yields of C3F7I and C3F7Br are especially good, making these useful perfluoropropyl intermediates readily available. Details of the reactions, especially the presence of low percentages of perfluoroisopropyl iodide and bromide in the products, are accounted for by proposed mechanisms involving halonium intermediates. Longer-chain primary iodides can also be added to tetrafluoroethylene, but the final products are predominantly fluoroolefins, with pentafluoroethyl iodide as a byproduct. In the case of the addition of C2F5I to tetrafluoroethylene, conditions for an efficient, low temperature dimerization of terafluoroethylene to F-butene-2 catalyzed by a combination of C2F5I/aluminum chlorofluoride have been defined. Evidence for an unusual transfer of I+ from the iodonium derivative of F-butene-2 to tetrafluoroethylene is presented.