75676-91-4Relevant academic research and scientific papers
Synthesis and cell growth inhibitory properties of substituted (E)-1-phenylbut-1-en-3-ones
Ducki, Sylvie,Hadfield, John A.,Hepworth, Lucy A.,Lawrence, Nicholas J.,Ching-Ying, Liu,McGown, Alan T.
, p. 3091 - 3094 (2007/10/03)
A series of (E)-1-phenylbut-1-en-3-ones, based on the naturally occurring (E)-1-(4'-hydroxyphenyl)but-1-en-3-one [IC50 (K562) 60 μM], was synthesised and screened for cytotoxic activity against the K562 human leukaemia cell line. (E)-1-(Pentafluorophenyl)but-1-en-3-one [IC50 (K562) 1.8 μM] was found to be over 30-fold more active than 1.
SYNTHESES OF DIHYDROISOCOUMARINS, (+/-)-HYDRANGENOL AND (+/-)-PHYLLODULCIN, UTILIZING AN ANNELATION REACTION OF ENAMINONES WITH ETHYL ACETOACETATE. STUDIES ON THE β-CARBONYL COMPOUNDS CONNECTED WITH THE β-POLYKETIDES XIII
Takeuchi, Naoki,Nakano, Takako,Goto, Kaori,Tobinaga, Seisho
, p. 289 - 297 (2007/10/02)
Naturally occurring dihydroisocoumarins, (+/-)-hydrangenol (1) and (+/-)-phyllodulcin (2) were synthesized from the enaminones (3) and (4) by the annelation reactions with ethyl acetoacetate (5).
Substituted cyclohexanediones and their herbicidal use
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, (2008/06/13)
The present disclosure is directed to substituted cyclohexanedione compounds, the preparation of said compounds, compositions containing said compounds and the use of said compositions in the selective pre- and postemergent kill and control of grassy weeds in the presence of various crop plants.
Substituted cyclohexanediones and their herbicidal uses
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, (2008/06/13)
The present disclosure is directed to substituted cyclohexanedione compounds, the preparation of said compounds, compositions containing said compounds and the use of said compositions in the selective pre- and postemergent kill and control of grassy weed
A novel route to cyclopropyl ketones, aldehydes, and carboxylic acids
Rodriques, Karen E.
, p. 1275 - 1278 (2007/10/02)
Cyclopropanation of α,β-unsaturated N-methoxy-N-methyl amides provided the cyclopropyl amides in far superior yields to those obtained with the corresponding ketones. The desired ketones are then readily accessible by the addition of organometallic reagents. Access to a variety functional groups, including aldehydes and carboxylic acids, is also described.
Mevalonolactone derivatives
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, (2008/06/13)
This invention concerns novel mevalonolactone derivatives having the formula STR1 wherein A represents a direct linkage, methylene, ethylene, trimethylene or vinylene group; R1 represents hydrogen atom, or an aliphatic acyl group, benzoyl group, or a benzoyl group substituted with hydroxy, lower alkoxy, aliphatic acyloxy or halogen; R2 represents hydrogen atom, a halogen atom or methyl group; and R3, R4 and R5 are same or different and each represents hydrogen atom, a halogen atom, a lower alkyl group with or without halogen as the substituent, phenyl group, or a phenyl group substituted with halogen, lower alkoxy, aliphatic acyloxy or lower alkyl with or without halogen, or a group represented by the formula R6 O-- (in the formula, R6 means hydrogen atom, an aliphatic acyl group, benzoyl group, phenyl group, a phenylalkyl group, cinnamyl group, or a group of benzoyl, phenyl, phenylalkyl or cinnamyl in all of which the aromatic ring is substituted with hydroxy, halogen, lower alkoxy, aliphatic acyloxy or lower alkyl with or without halogen as the substituent, or a lower alkyl group with or without halogen as the substituent). The compounds are useful for the treatment of hyperlipidemia. They may be prepared by halo-lactonizing the corresponding γ,δ-unsaturated carboxylic acid derivatives and optionally dehalogenating the resulting product, or lactonizing the corresponding δ-hydroxy-carboxylic acid derivatives.
