75710-99-5

Basic information

• Product Name: 3-Methoxy-5-nitropyridin-2-ol
• Synonyms: 3-METHOXY-5-NITRO-PYRIDIN-2-OL;2-Hydroxy-3-methoxy-5-nitropyridine;3-Methoxy-5-nitropyridin-2(1H)-one;3-methoxy-5-nitro-2(1H)-Pyridinone;3-Methoxy-5-nitropyridin-2-ol, 3-Methoxy-5-nitropyridin-2(1H)-one
• CAS NO: 75710-99-5
• Molecular Formula: C6H6N2O4
• Molecular Weight: 170.12
• Product Categories: Pyridine
• Mol File: 75710-99-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 345.7 °C at 760 mmHg
• Flash Point: 162.9 °C
• Appearance: /
• Density: 1.42 g/cm³
• Vapor Pressure: 6.03E-05mmHg at 25°C
• Refractive Index: 1.561
• Storage Temp.: 2-8°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 8.53±0.10(Predicted)
• CAS DataBase Reference: 3-Methoxy-5-nitropyridin-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Methoxy-5-nitropyridin-2-ol(75710-99-5)
• EPA Substance Registry System: 3-Methoxy-5-nitropyridin-2-ol(75710-99-5)

Safety Data

• Hazardous Substances Data: 75710-99-5(Hazardous Substances Data)

Usage

Uses

3-Methoxy-5-nitro-pyridin-2-ol

InChI:InChI=1/C6H6N2O4/c1-12-5-2-4(8(10)11)3-7-6(5)9/h2-3H,1H3,(H,7,9)

Upstream product

• 84719-32-4 3-Hydroxy-2(1H)-pyridinone 
• 20928-63-6 3-methoxy-1H-pyridin-2-one 
• 20928-63-6 3-methoxy-2-hydroxypyridine 
• 16867-04-2 dihydroxypyridine 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 1419604-03-7 phenyl 5-methoxy-6-(pyrrolidin-1-yl)pyridin-3-ylcarbamate 
• 1419600-65-9 1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3-(5-methoxy-6-(pyrrolidin-1-yl)pyridin-3-yl)urea 
• 872355-75-4 C₁₆H₂₂N₂O₄Si 
• 872355-74-3 ethyl 3-methoxy-5-amino-6-trimethylsilylacetylenepyridine-2-carboxylate 
• 872355-72-1 ethyl 3-methoxy-5-aminopyridine-2-carboxylate 
• 75711-01-2 6-chloro-5-methoxypyridin-3-amine 
• 75711-00-1 2-chloro-3-methoxy-5-nitropyridine 

Relevant articles and documents

SUBSTITUTED HETEROAROMATIC PYRAZOLE-CONTAINING CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS

The invention relates to substituted heteroaromatic pyrazole-containing carboxamide and urea derivatives as vanilloid receptor ligands, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

An efficient large-scale synthesis of alkyl 5-hydroxy-pyridin- and pyrimidin-2-yl acetate

The synthesis of methyl 2-(5-hydroxy-3-methoxypyridin-2-yl)acetate and alkyl 2-(5-hydroxypyrimidin-2-yl)acetate is described. Methodology for an efficient access to 5-hydroxy-pyridin- and pyrimidin-2-yl acetate cores has been developed. Based on the difference in halogen reactivity, 5-bromo-2-chloropyridine and its pyrimidine analogue were functionalized judiciously by SNAr and palladium-catalyzed reactions. The outlined strategy provides a high-yielding route suitable for large-scale synthesis of these compounds as well as paves the way for a potential rapid access to other heterocyclic analogues.

AZAINDOLE DERIVATIVES AS INHIBITORS OF P38 KINASE

The invention is directed to methods to inhibit p38 kinase, preferably p38-α using compounds which are azaindoles wherein the azaindoles are coupled through an azacyclic linker to another cyclic moiety.