4-(4-AMino-3-fluorophenoxy)-pyridine-2-carboxylic acid aMide

Base Information

Chemical Name:4-(4-AMino-3-fluorophenoxy)-pyridine-2-carboxylic acid aMide
CAS No.:757251-54-0
Molecular Formula:C12H10FN3O2
Molecular Weight:247.229
Hs Code.:
Mol file:757251-54-0.mol

Synonyms:4-(6-chloro-pyrimidin-4-yloxy)-2-fluoro-phenylamine;4-(4-amino-3-fluorophenoxy)pyridine-2-carboxyamide;4-(4-amino-3-fluorophenoxy)pyridine-2-carboxamide;4-(4-amino-3-fluorophenoxy)-6-chloropyrimidine;4-(4-amino-3-fluorophenoxy)picolinamide;Benzenamine,4-[(6-chloro-4-pyrimidinyl)oxy]-2-fluoro;

Suppliers and Price of 4-(4-AMino-3-fluorophenoxy)-pyridine-2-carboxylic acid aMide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-?(4-?Amino-?3-?fluorophenoxy)?pyridine-?2-?carboxamide
250mg
$ 70.00

TRC
4-?(4-?Amino-?3-?fluorophenoxy)?pyridine-?2-?carboxamide
10g
$ 575.00

American Custom Chemicals Corporation
4-(4-AMINO-3-FLUORO-PHENOXY)-PYRIDINE-2-CARBOXYLIC ACID AMIDE 95.00%
5MG
$ 502.15

Total 7 raw suppliers

Chemical Property of 4-(4-AMino-3-fluorophenoxy)-pyridine-2-carboxylic acid aMide

Chemical Property:

PSA：91.23000
Density:1.385
LogP:2.97560
Storage Temp.:Hygroscopic, Refrigerator, under inert atmosphere
Solubility.:Acetontrile (Slightly, Heated), Chloroform (Slightly, Heated)

Purity/Quality:

99%, ^*data from raw suppliers

4-?(4-?Amino-?3-?fluorophenoxy)?pyridine-?2-?carboxamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 4-?(4-?Amino-?3-?fluorophenoxy)?pyridine-?2-?carboxamide is a reagent used in the synthesis of heterocyclic urea derivatives as kinase inhibitors in the treatment of myeloproliferative and other diseases.

Technology Process of 4-(4-AMino-3-fluorophenoxy)-pyridine-2-carboxylic acid aMide

There total 4 articles about 4-(4-AMino-3-fluorophenoxy)-pyridine-2-carboxylic acid aMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.3%

: 99586-65-9
4-chloropicolinamide

: 399-95-1
4-amino-3-fluorophenol

: 757251-54-0
4-(4-amino-3-fluorophenoxy)pyridine-2-carboxyamide

Guidance literature:: 4-amino-3-fluorophenol; With potassium tert-butylate; In tetrahydrofuran; dimethyl sulfoxide; at 10 - 20 ℃; for 0.166667h; Inert atmosphere; Large scale;

4-chloropicolinamide; In tetrahydrofuran; dimethyl sulfoxide; at 80 - 85 ℃; for 2.66667h; Temperature; Large scale;

Reference yield: 75.3%

: 99586-65-9
4-chloropicolinamide

: 4-amino-3-fluorophenol 1/2 naphthalene-2,6-disulfonate

: 757251-54-0
4-(4-amino-3-fluorophenoxy)pyridine-2-carboxyamide

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; dimethyl sulfoxide; at 0 - 90 ℃; for 2.5h; Product distribution / selectivity;

Reference yield: 74.3%

: 99586-65-9
4-chloropicolinamide

: 757251-54-0
4-(4-amino-3-fluorophenoxy)pyridine-2-carboxyamide

Guidance literature:: 4-amino-3-fluorophenol; With potassium tert-butylate; In dimethyl sulfoxide; at 20 ℃; for 0.25h;

4-chloropicolinamide; In dimethyl sulfoxide; at 80 ℃; for 0.833333h;