75762-56-0

Basic information

• Product Name: 3-BROMO-4'-CHLOROBENZOPHENONE
• Synonyms: 3-BROMO-4'-CHLOROBENZOPHENONE;(3-BROMOPHENYL)(4-CHLOROPHENYL)METHANONE
• CAS NO: 75762-56-0
• Molecular Formula: C₁₃H₈BrClO
• Molecular Weight: 295.56
• Mol File: 75762-56-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 391.2°C at 760 mmHg
• Flash Point: 190.4°C
• Appearance: /
• Density: 1.51g/cm³
• Vapor Pressure: 2.51E-06mmHg at 25°C
• Refractive Index: 1.618
• CAS DataBase Reference: 3-BROMO-4'-CHLOROBENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-4'-CHLOROBENZOPHENONE(75762-56-0)
• EPA Substance Registry System: 3-BROMO-4'-CHLOROBENZOPHENONE(75762-56-0)

Safety Data

• Hazardous Substances Data: 75762-56-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H8BrClO/c14-11-3-1-2-10(8-11)13(16)9-4-6-12(15)7-5-9/h1-8H

Upstream product

• 98-60-2 4-chlorobenzenesulfonyl chloride 
• 2042-37-7 o-cyanobromobenzene 
• 14752-66-0 sodium p-chlorobenzenesulphinate 
• 108-36-1 1,3-dibromobenzene 
• 122334-37-6 4-chloro-N-methoxy-N-methylbenzamide 
• 1711-09-7 3-bromobenzoyl chloride 
• 108-90-7 chlorobenzene 

Downstream Products

• 1220124-11-7 [(3-bromophenyl)-(4-chlorophenyl)ketone]thiosemicarbazone 
• 1374584-05-0 (4-chlorophenyl)(3-bromophenyl)pyrid-3-yl methanol 
• 92188-90-4 1-bromo-3-(4-chlorobenzyl)benzene 

Relevant articles and documents

Palladium(II)-catalyzed desulfitative synthesis of aryl ketones from sodium arylsulfinates and nitriles: Scope, limitations, and mechanistic studies

A fast and efficient protocol for the palladium(II)-catalyzed production of aryl ketones from sodium arylsulfinates and various organic nitriles under controlled microwave irradiation has been developed. The wide scope of the reaction has been demonstrated by combining 14 sodium arylsulfinates and 21 nitriles to give 55 examples of aryl ketones. One additional example illustrated that, through the choice of the nitrile reactant, benzofurans are also accessible. The reaction mechanism was investigated by electrospray ionization mass spectrometry and DFT calculations. The desulfitative synthesis of aryl ketones from nitriles was also compared to the corresponding transformation starting from benzoic acids. Comparison of the energy profiles indicates that the free energy requirement for decarboxylation of 2,6-dimethoxybenzoic acid and especially benzoic acid is higher than the corresponding desulfitative process for generating the key aryl palladium intermediate. The palladium(II) intermediates detected by ESI-MS and the DFT calculations provide a detailed understanding of the catalytic cycle. (Figure Presented).

Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors

A small library of 36 functionalized benzophenone thiosemicarbazone analogs has been prepared by chemical synthesis and evaluated for their ability to inhibit the cysteine proteases cathepsin L and cathepsin B. Inhibitors of cathepsins L and B have the potential to limit or arrest cancer metastasis. The six most active inhibitors of cathepsin L (IC50 50 > 10,000 nM). The most active analog in the series, 3-bromophenyl-2′-fluorophenyl thiosemicarbazone 1, also efficiently inhibits cell invasion of the DU-145 human prostate cancer cell line.