75787-20-1

Basic information

• Product Name: 3-Nitro-8-(4-nitro-phenyl)-5,6-dihydro-imidazo[1,2-d][1,4]oxazepine
• CAS NO: 75787-20-1
• Molecular Weight: 302.246
• Mol File: 75787-20-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-Nitro-8-(4-nitro-phenyl)-5,6-dihydro-imidazo[1,2-d][1,4]oxazepine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Nitro-8-(4-nitro-phenyl)-5,6-dihydro-imidazo[1,2-d][1,4]oxazepine(75787-20-1)
• EPA Substance Registry System: 3-Nitro-8-(4-nitro-phenyl)-5,6-dihydro-imidazo[1,2-d][1,4]oxazepine(75787-20-1)

Safety Data

• Hazardous Substances Data: 75787-20-1(Hazardous Substances Data)

Upstream product

• 13182-82-6 acetic acid 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl ester 
• 443-48-1 metronidazole 
• 122-04-3 4-nitro-benzoyl chloride 
• 75787-16-5 C₂₇H₁₈N₆O₁₂ 
• 75787-23-4 1-(2-Acetoxyethyl)-5-nitro-2-imidazole-α-(p-nitrophenyl)ethenol-p-nitrobenzoate 

Relevant articles and documents

Aroylation of Metronidazole: Synthesis of Imidazo-1,4-oxazepines

Reaction of metronidazole (I) with benzoyl chloride, p-nitrobenzoyl chloride, p-chlorobenzoyl chloride and 2-thenoyl chloride yields the corresponding 2-enol benzoates (e.g.II).Hydrolysis with ethanolic hydrochloric acid yields the expected ketones (IV) while hydrolysis with 1:1 sulphuric acid gives derivatives of the novel imidazo-1,4-oxazepine ring system (e.g.VI).