75844-68-7

Basic information

• Product Name: TERT-BUTYL 2,3-DIHYDRO-2-OXO-3-OXAZOLECARBOXYLATE
• Synonyms: TERT-BUTYL 2,3-DIHYDRO-2-OXO-3-OXAZOLECARBOXYLATE
• CAS NO: 75844-68-7
• Molecular Formula: C₈H₁₁NO₄
• Molecular Weight: 0
• Mol File: 75844-68-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 223.9°C at 760 mmHg
• Flash Point: 89.2°C
• Appearance: /
• Density: 1.252g/cm³
• Vapor Pressure: 0.094mmHg at 25°C
• Refractive Index: 1.501
• CAS DataBase Reference: TERT-BUTYL 2,3-DIHYDRO-2-OXO-3-OXAZOLECARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL 2,3-DIHYDRO-2-OXO-3-OXAZOLECARBOXYLATE(75844-68-7)
• EPA Substance Registry System: TERT-BUTYL 2,3-DIHYDRO-2-OXO-3-OXAZOLECARBOXYLATE(75844-68-7)

Safety Data

• Hazardous Substances Data: 75844-68-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H11NO4/c1-8(2,3)13-7(11)9-4-5-12-6(9)10/h4-5H,1-3H3

Upstream product

• 27584-70-9 4-oxazolin-2-one 
• 75-65-0 tert-butyl alcohol 
• 503-38-8 trichloromethyl chloroformate 
• 75-44-5 phosgene 

Downstream Products

• 15761-38-3 L-N-Boc-Ala 
• 2592-18-9 Boc-Thr-OH 
• 13726-67-5 Boc-Asp-OH 
• 2188-18-3 Boc-Arg(NO₂)-OH 
• 15761-39-4 N^α-(tert-butyloxycarbonyl)-L-proline 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 13139-14-5 Boc-Trp-OH 
• 42116-44-9 N-tert-butoxycarbonylbenzylamine 
• 4530-20-5 BOC-glycine 
• 1138-80-3 N-(Benzyloxycarbonyl)glycine 
• 13139-14-5 N-(tert-Butyloxycarbonyl)-L-tryptophan 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 2488-15-5 N-tert-butoxycarbonyl-L-methionine 
• 13139-16-7 N-(tert-butyloxycarbonyl)-L-isoleucine 

Relevant articles and documents

3-Alkoxycarbonyl-2-oxazolones and Their Homopolymers as Highly Preservable Amino-Protecting Reagents. tert-Butoxy-carbonylation and Benzyloxycarbonylation of Amino Groups

Highly preservable amino protecting reagents derived from the 2-oxazolone moiety as a common activating mediator have been developed. 3-Alkoxycarbonyl-2-oxazolones serve as easily handled reagents for amino protection, including tert-butoxycarbonylation, benzyloxycarbonylation, p-methoxybenzyloxycarbonylation, methoxycarbonylation and ethoxycarbonylation.For example, high yield N-protection of α-amino acids has been smoothly performed by the use of 3-tert-butoxycarbonyl and 3-benzyloxycarbonyl-2-oxazolones in aqueous solution at room temperature.A series of homopolymers, poly(3-alkoxycarbonyl-2-oxazolone), is readily obtainable by radical-initiated chain reaction of the corresponding 4,5-unsubstituted oxazolone monomers (except for the tert-butoxy derivate, which failed to give polymeric compounds), and these were successfully used for amino protection as well.Use of the polymer reagents greatly simplifies the purification procedure, though a longer reaction time is required.Keywords - 3-alkoxycarbonyl-2-oxazolone; poly(2-alkoxycarbonyl-2-oxazolone); 3-tert-butoxycarbonyl-2-oxazolone; 3-benzyloxycarbonyl-2-oxazolone; amino protection