758692-16-9Relevant academic research and scientific papers
Access to skipped polyene macrolides through ring-closing metathesis: Total synthesis of the RNA polymerase inhibitor ripostatin B
Winter, Philipp,Hiller, Wolf,Christmann, Mathias
supporting information; experimental part, p. 3396 - 3400 (2012/06/16)
Rip-Roaring! A convergent total synthesis of antibiotic ripostatin B was developed. A key step in the synthesis is a metathesis reaction allowing for a ring closure to the labile doubly skipped triene macrolide. Copyright
Transforming terpene feedstock into polyketide architecture
Winter, Philipp,Vaxelaire, Carine,Heinz, Christoph,Christmann, Mathias
, p. 394 - 396 (2011/03/17)
The Cu-catalyzed synthesis of skipped 1,4-dienes from allylic acetates and vinyl-Grignard reagents is key to bidirectional modifications of acyclic terpene acetates. As a result, trisubstituted double bond containing subunits can be readily transferred into complex polyketides from inexpensive bulk terpenes.
General approach to polycyclic meroterpenoids based on Stille couplings and titanocene catalysis
Justicia, Jose,Oltra, J. Enrique,Cuerva, Juan M.
, p. 5803 - 5806 (2007/10/03)
We describe a novel convergent procedure that has proved useful in the synthesis of a wide range of meroterpenoid-related structures containing a mono-, sesqui-, or diterpenoid moiety linked to a nonfused aromatic subunit with various substitution pattern
