75887-43-3Relevant articles and documents
Resolution of chiral (trimethylenemethane) iron (tricarbonyl) complexes
Franck-Neumann, Michel,Stoeber, Paul,Passmore, Guy
, p. 3193 - 3202 (1996)
Reaction of (S)-(-)-ethyl lactate and (R)-(+)-α-methylbenzylamine with the racemic crystalline activated TMM ester 3, obtained in 3 steps from β,β'-dimethylacrylic acid, provides the easily separable diastereomeric esters 2a/2b and amides 10a/10b. From the esters and the N-BOC amides 11a/11b, simple reactions allow the synthesis of other optically active TMM Fe(CO)3 complexes of high enantiomeric purity and known absolute configuration. Copyright (C) Elsevier Science Ltd.
Application of the palladium-catalysed norbornene-assisted catellani reaction towards the total synthesis of (+)-linoxepin and isolinoxepin
Qureshi, Zafar,Weinstabl, Harald,Suhartono, Marcel,Liu, Hongqiang,Thesmar, Pierre,Lautens, Mark
supporting information, p. 4053 - 4069 (2014/07/08)
Our ongoing effort towards the development of highly selective transition-metal-catalysed C-H activation processes has led to the expansion of the Catellani reaction. In a Pd0/PdII/Pd IV-catalysed domino reaction, an aryl iodide, alkyl iodide and tert-butyl acrylate were combined to synthesize the carbon framework of the novel lignan (+)-linoxepin. The enantioselective synthesis highlights the work accomplished in our group and provides an excellent procedure for the reliable and scalable synthesis of architecturally complex scaffolds. This report outlines the synthetic approaches towards this interesting class of biologically active molecules. After the key Catellani/Heck reaction, our synthesis features a Leimeux-Johnson oxidation and a titanium tetrachloride mediated aldol condensation. Finally, a tuneable Mizoroki-Heck reaction was performed to furnish not only the natural product (+)-linoxepin but also its isoform, which we have named isolinoxepin. The enantioselective total synthesis of the natural product (+)-linoxepin has been accomplished in eight steps starting from commercial materials. The key Pd-catalysed Catellani step served to combine aryl iodide, alkyl iodide and tert-butyl acrylate in a domino sequence. By tuning the final Heck reaction, both the natural product and its structural isomer were synthesized. Copyright
Triazole-dithiocarbamate based selective lysine specific demethylase 1 (LSD1) inactivators inhibit gastric cancer cell growth, invasion, and migration
Zheng, Yi-Chao,Duan, Ying-Chao,Ma, Jin-Lian,Xu, Rui-Min,Zi, Xiaolin,Lv, Wen-Lei,Wang, Meng-Meng,Ye, Xian-Wei,Zhu, Shun,Mobley, David,Zhu, Yan-Yan,Wang, Jun-Wei,Li, Jin-Feng,Wang, Zhi-Ru,Zhao, Wen,Liu, Hong-Min
, p. 8543 - 8560 (2013/12/04)
Lysine specific demethylase 1 (LSD1), the first identified histone demethylase, plays an important role in epigenetic regulation of gene activation and repression. The up-regulated LSD1's expression has been reported in several malignant tumors. In the cu
