Resolution of chiral (trimethylenemethane) iron (tricarbonyl) complexes

Article abstract of DOI:10.1016/0957-4166(96)00422-3

Reaction of (S)-(-)-ethyl lactate and (R)-(+)-α-methylbenzylamine with the racemic crystalline activated TMM ester 3, obtained in 3 steps from β,β'-dimethylacrylic acid, provides the easily separable diastereomeric esters 2a/2b and amides 10a/10b. From the esters and the N-BOC amides 11a/11b, simple reactions allow the synthesis of other optically active TMM Fe(CO)₃ complexes of high enantiomeric purity and known absolute configuration. Copyright (C) Elsevier Science Ltd.